1921
Volume 70, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

In Nepal, many infections remain poorly characterized, partly due to limited diagnostic facilities. We studied consecutive febrile adults presenting to a general hospital in Kathmandu, Nepal. Of the 876 patients enrolled, enteric fever and pneumonia were the most common clinical diagnoses. Putative pathogens were identified in 323 (37%) patients, the most common being serotype Typhi and serotype Paratyphi A (117), (97), (53), spp. (36), and (28). Approximately half of the isolates were resistant to nalidixic acid. No clinical predictors were identified to reliably distinguish between the different infections. These findings confirm the heavy burden of enteric fever and pneumonia in Kathmandu, and highlight the importance of murine typhus, scrub typhus, and leptospirosis. Given the lack of reliable clinical predictors, the development of cheap and accurate diagnostic tests are likely to be of great clinical utility in this setting.

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  • Received : 06 Sep 2003
  • Accepted : 11 Nov 2003

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