Volume 70, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


We present a case of 23-year-old man with acute meningoencephalitis, accompanied by inflammation of a nasal ulcer. He had been healthy until six months prior to admission to the hospital when he had a motorcycle accident. A star-shaped wound at his nose was incurred after falling into a swamp. A computed tomogram of the brain showed two nonenhancing hypodense lesions at the left caudate nucleus and the right parietal lobe, ependymitis and leptomeningeal enhancement. A skin biopsy showed chronic noncaseous granulomatous inflammation without demonstrated microorganisms. The patient did not respond to the empirical treatment with cloxacillin, ceftriaxone, and amphotericin B, and eventually died on the thirteenth day of hospitalization. At autopsy, hematoxylin and eosin–stained brain sections showed a chronic necrotizing inflammation with numerous amebic trophozoites and rare cysts. Definitive identification of was made by fluorescent immunohistochemical analysis. There were 10 primary amebic meningoencephalitis, eight a granulomatous amebic encephalitis, and three meningitis in Thailand. To our knowledge, this case is the first reported case of in Southeast Asia.


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  • Received : 27 Aug 2003
  • Accepted : 30 Oct 2003

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