1921
Volume 70, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Lipid mediators play important roles in the pathogenesis of malaria. Phospholipase As are enzymes involved in the production of these mediators, and they function in inflammation. Among them, cytosolic phospholipase A (cPLA) is a key enzyme in the metabolism of arachidonic acid, the first intermediate in the production of lipid mediators. ANKA causes cerebral malaria in CL57B/6 mice, and we recently produced cPLA-deficient mice with this background. With the expectation of reduced pathogenicity, we performed experimental infection in these mice. Unexpectedly, the infected mice developed cerebral malaria and died at the same time as the control mice, while the parasitemia progressed similarly in both groups. These observations suggest that secretory PLAs rather than cPLA may be involved in the aggravation, although possible compensation by the induction of other enzymes has not been excluded. The present findings are expected to help clarify the involvement of various phospholipase As in malaria.

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  • Received : 19 Mar 2003
  • Accepted : 02 Feb 2004

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