1921
Volume 70, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

We describe antibody isotype patterns resulting from infection among 155 individuals 5–76 years old from a community in Leyte, The Philippines. Their exposure, infection, and reinfection status had been observed in a previously described water contact study used to categorically classify them as putative resistant or susceptible individuals. Antigens tested for specific antibody isotype responses were soluble worm antigen preparation (SWAP) and soluble egg antigen (SEA) and a panel of recombinant molecules. The study was aimed primarily at evaluating antigen-specific antibody responses and their potential in inducing protection among putative resistant individuals. Specific antibody responses suggestive of an involvement in protection were an IgE response to SWAP among females less than 20 years of age (5–19) and IgA responses to SWAP in the younger (5–19 years) age groups. Compatible with other studies on human schistosomes, IgM reactivities to SWAP and SEA in the 5–19-year-old age group predicted susceptibility as did IgG4 responses to recombinant paramyosin.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2004.70.549
2004-05-01
2017-11-21
Loading full text...

Full text loading...

/deliver/fulltext/14761645/70/5/0700549.html?itemId=/content/journals/10.4269/ajtmh.2004.70.549&mimeType=html&fmt=ahah

References

  1. Butterworth AE, Capron M, Cordingley JS, Dalton PR, Dunne DW, Karinki HC, Kimani G, Koech D, Mugambi M, Ouma JH, Prentice MA, Richardson BA, Arap Siongok TK, Sturrock RF, Taylor DW, 1985. Immunity after treatment of human schistosomiasis mansoni: II. Identification of resistant individuals and analysis of the immune responses. Trans R Soc Trop Med Hyg 79 : 393–408.
  2. Butterworth AE, Curry AJ, Dunne DW, Fulford AJC, Kimani G, Kariuki HC, Klumpp R, Koech D, Mbugua G, Ouma JH, Roberts M, Thiongo FW, Capron A, Sturrock RF, 1994. Immunity and morbidity in human schistosomiasis mansoni. Trop Geogr Med 46 : 197–208.
  3. Sturrock RF, 1987. Immunity after treatment of human schistosomiasis mansoni: III. Long-term effects of treatment and retreatment. Trans R Soc Trop Med Hyg 81 : 303–314.
  4. Sturrock RF, Kimani R, Cottrell BJ, Butterworth AE, Seitz HM, Siongok TK, Houba V, 1983. Observations on possible immunity to reinfection among Kenyan schoolchildren after treatment for Schistosoma mansoni. Trans R Soc Trop Med Hyg 77 : 363–371.
  5. Hagan P, Blumenthal UJ, Chaudri M, Greenwood BM, Hayes RJ, Hodgson J, Kelly C, Knight M, Simpson AJG, Smithers SR, Wilkins HA, 1987. Resistance to reinfection with Schistosoma haematobium in Gambian children: analysis of their immune responses. Trans R Soc Trop Med Hyg 81 : 939–946.
  6. Olveda RM, Daniel B, Ramirez BL, Aligui GdL, Acosta LP, Fevidal P, Tiu E, De Veyra F, Peters P, Romulo R, Domingo EO, Weist PM, Olds GR, 1996. Schistosomiasis japonica in the Philippines: the long term impact of population-based chemotherapy on infection, transmission and morbidity. J Infect Dis 174 : 163–172.
  7. Ross AGP, Sleigh AC, Li YS, Williams GM, Aligui GdL, Mc-Manus DP, 2000. Is there immunity to Schistosoma japonicum? Parasitol Today 16 : 159–164.
  8. Hagan P, Ndhlovu PD, Dunne DW, 1998. Schistosome immunology: more questions than answers. Parasitol Today 14 : 407–422.
  9. Wilkins H, Blumenthal U, Hagan P, Hayes R, Tullock S, 1987. Resistance to reinfection after treatment of urinary schistosomiasis. Trans R Soc Trop Med Hyg 81 : 29–35.
  10. Hagan P, Blumenthal U, Dunne DW, Simpson AJG, Wilkins HA, 1991. Human IgE, IgG4 and resistance to reinfection with Schistosoma haematobium. Nature 149 : 243–245.
  11. Dunne DW, Butterworth AE, Fulford AJC, Kariuki HC, Langley JG, Ouma JH, Capron A, Pierce RJ, Sturrock RF, 1992. Immunity after treatment of human schistosomiasis mansoni: association between IgE antibodies to adult worm antigens and resistance to reinfection. Eur J Immunol 22 : 1483–1494.
  12. Rihet P, Demeure CE, Bourgois A, Prata A, Dessein AJ, 1991. Evidence for an association between human resistance to Schistosoma mansoni and high anti-larval IgE levels. Eur J Immunol 21 : 2679–2686.
  13. Ndhlovu P, Cadman H, Vennervald BJ, Christensen NO, Chidimu M, Chandiwana SK, 1996. Age-related antibody profiles in S. haematobium infections in a rural community in Zimbabwe. Parasite Immunol 18 : 181–191.
  14. Capron M, Tomassini M, Torpier G, Kusnierz JP, MacDonald S, Capron A, 1989. Selectivity of mediators released by eosinophils. Arch Allergy Applied Immunol 88 : 54–58.
  15. Gryzch JM, Grezel D, Xu CB, Neyrick JL, Capron M, Ouma JH, Butterworth AE, Capron A, 1993. IgA antibodies to a protective antigen in human schistosomiasis mansoni. J Immunol 150 : 527–535.
  16. Boctor FN, Peter JB, 1990. IgG subclasses in human schistosomiasis: over-production of schistosome-specific and non-specific IgG4. Clin Exp Immunol 82 : 574–578.
  17. Webster M, Ramirez BL, Aligui G, Olveda RM, Ouma JH, Kariuki HC, Kimani G, Olds GR, Fulford AJC, Butterworth AE, Dunne DW, 1997. The influence of sex and age on antibody isotype responses to Schistosoma mansoni and Schistosoma japonicum in human populations in Kenya and the Philippines. Trans R Soc Trop Med Hyg 64 : 4042–4062.
  18. Zhang Z, Wy H, Chen S, Hu L, Xie Z, Qui Y, Su C, Cao JP, Wu Y, Zhang S, Wu G, 1997. Association between IgE antibody against soluble egg antigen and resistance to reinfection with Schistosoma japonicum. Trans R Soc Trop Med Hyg 91 : 606–608.
  19. Hernandez MG, Hafalla JC, Acosta LP, Aligui FF, Aligui GD, Ramirez BL, Dunne DW, Santiago ML, 1999. Paramyosin is a major target of the human IgA response against Schistosoma japonicum. Parasite Immunol 21 : 641–647.
  20. McManus DP, Wong JYM, Zhou J, Cai C, Zeng Q, Smyth D, Li Y, Kalinna BH, Duke MJ, Yi X, 2002. Recombinant paramyosin (rec-Sj-97) tested for immunogenicity and vaccine efficacy against Schistosoma japonicum in mice and water buffaloes. Vaccine 20 : 870–878.
  21. Acosta LP, Aligui GdL, Tiu WU, McManus DP, Olveda RM, 2002. Immune correlate study on human Schistosoma japonicum in a well-defined population in Leyte, Philippines: I. Assessment of ‘resistance’ versus ‘susceptibility’ to Schistosoma japonicum infection. Acta Trop 84 : 127–136.
  22. Acosta LP, Waine G, Aligui GdL, Tiu WU, Olveda RM, Mc-Manus DP, 2002. Immune correlate study on human Schistosoma japonicum in a well-defined population in Leyte, Philippines: II. Cellular immune responses to Schistosoma japonicum recombinant and native antigens. Acta Trop 84 : 137–149.
  23. Kalinna BH, Becker M, McManus DP, 1997. Engineering and expression of a full length cDNA encoding Schistosoma japonicum paramyosin. Acta Trop 65 : 111–115.
  24. Waine GJ, Becker MM, Yang M, Kalinna BH, McManus DP, 1993. Cloning, molecular characterization, and functional activity of Schistosoma japonicum glyceraldehyde-3-phosphate dehydrogenase, a putative vaccine candidate against schistosomiasis japonica. Infect Immun 61 : 4716–4723.
  25. Waine GJ, Becker MM, Scott JC, Kalinna BH, Yang W, Mc-Manus DP, 1994. Purification of a recombinant Schistosoma japonicum antigen homologous to the 22 kDa membrane-associated antigen of S. mansoni, a putative vaccine candidate against schistosomiasis. Gene 142 : 259–263.
  26. Becker MM, Kalinna BH, Waine GW, McManus DP, 1994. Cloning, overproduction, and purification of a functionally active cytoplasmic fatty acid binding protein (SjFABPc) from the human bloodfluke, Schistosoma japonicum. Gene 148 : 321–325.
  27. Scott JC, McManus DP, 2000. Molecular cloning and enzymatic expression of the 28-kDa glutathione S-transferase of Schistosoma japonicum: evidence for sequence variation but lack of consistent vaccine efficacy in the murine host. Parasitol Int 49 : 289–300.
  28. Smithers SR, Terry RJ, 1965. Naturally acquired resistance to experimental infections of Schistosoma mansoni in the rhesus monkey (Macaca mulatta). Parasitology 55 : 701–710.
  29. Li YS, Ross AGP, Sleigh AC, Li Y, Waine GJ, Williams GM, Tanner M, McManus DP, 1999. Antibody isotype responses, infection and re-infection for Schistosoma japonicum in a marshland area of China. Acta Trop 73 : 79–92.
  30. Li YS, Ross AGP, Sleigh AC, Li Y, Waine GJ, Williams GM, Tanner M, McManus DP, 2001. Human susceptibility to Schistosoma japonicum in China correlates with antibody isotypes to native antigens. Trans R Soc Trop Med Hyg 95 : 441–448.
  31. Gryseels B, 1994. Human resistance to Schistosoma infections: age or experience? Parasitol Today 10 : 380–384.
  32. Fulford AJC, Webster M, Ouma JH, Kimani G, Dunne DW, 1998. Puberty and age-related changes in susceptibility to schistosome infection. Parasitol Today 14 : 23–26.
  33. Ross AG, Bartley PJ, Sleigh AC, Olds GR, Li YS, Williams GM, McManus DP, 2002. Schistosomiasis. N Engl J Med 346 : 1212–1220.
  34. Jeannin P, Lecoanet S, Delneste Y, Gauchat JF, Bonnefoy JY, 1998. IgE versus IgG4 production can be differentially regulated by IL-10. J Immunol 160 : 3555–3561.
  35. McManus DP, 2000. The development of vaccines for schistosomiasis. Curr Opin Anti-infective Invest Drugs 2 : 24–34.
  36. Capron A, Riveau GJ, Bartley PB, McManus DP, 2002. Prospects for a schistosome vaccine. Curr Drug Targets Immune Endocr Metabol Disord 2 : 281–290.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2004.70.549
Loading
/content/journals/10.4269/ajtmh.2004.70.549
Loading

Data & Media loading...

  • Received : 28 May 2003
  • Accepted : 08 Aug 2003

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error