1921
Volume 70, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

drug sensitivity to chloroquine (CQ), mefloquine (MQ) and quinine was investigated in 60 culture-adapted isolates from malaria patients in Padrecocha, a village in the Amazonian Department of Loreto, Peru. All isolates showed resistance to CQ, decreased susceptibility to quinine, and sensitivity to MQ. These isolates were examined for mutations in the multidrug resistance 1 () and chloroquine resistance transporter () genes previously linked to CQ resistance. The mutations N86Y and D1246Y, two of the five mutations commonly observed in the gene of CQ-resistant clones, were not found. The mutation K76T, associated with CQ resistance, was identified in all the isolates tested. Sequence analysis of codons 72–76 in the gene showed the haplotypes SVMNT and CVMNT.

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2004-05-01
2017-11-21
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  • Received : 03 Feb 2003
  • Accepted : 29 Aug 2003

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