1921
Volume 70, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Hematocrit levels were determined in 36 mothers living at high altitudes (3,750 meters) and their infant cord bloods to determine the effect of maternal anemia on the infant. The arterial oxygen saturation (SaO) and respiratory rate of the infants were also followed during the first four months of life. There was a negative correlation between maternal hematocrit and infant hematocrit (r = − 0.57). Nineteen babies born to anemic women (hematocrit < 41%) had a significantly higher mean hematocrit (59.9%) than those born to non-anemic mothers (55.8%; = 0.003). The SaO levels and respiratory rates of infants were not different between infants born to non-anemic and anemic mothers. At high altitudes, infants from mothers with anemia have higher hematocrits than those born to non-anemic mothers.

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2004-04-01
2017-09-22
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References

  1. Gamboa R, Marticorena E, 1971. Presión arterial pulmonar en el recién nacido en las grandes alturas. Arch Inst Biol Andina 4 : 55–56.
  2. Khalid ME, Ali ME, Ali KZ, 1997. Full-term birth weight and placental morphology at high and low altitude. Int J Gynaecol Obstet 57 : 259–265.
  3. Jensen GM, Moore LG, 1997. The effect of high altitude and other risk factors on birth weight: independent or interactive effect? Am J Public Health 87 : 1003–1007.
  4. Ballew C, Haas JD, 1986. Hematologic evidence of fetal hypoxia among newborn infants at high altitude in Bolivia. Am J Obstet Gynecol 155 : 66–69.
  5. Zamudio S, Droma T, Norkyel KY, 1993. Protection from intra-uterine growth retardation in Tibetans at high altitude. Am J Phys Anthropol 91 : 215–224.
  6. Niermeyer S, Yang P, Shanmina, Drolkar, Zhuang J, Moore LG, 1995. Arterial oxygen saturation in Tibetan and Han infants born in Lhasa, Tibet. N Engl J Med 333 : 1248–1252.
  7. Moore LG, Zamudio S, Zhuang J, Sun S, Droma T, 2001. Oxygen transport in Tibetan woman during pregnancy at 3,658 M. Am J Phys Anthropol 144 : 42–53.
  8. Moore LG, 2001. Human genetic adaptation to high altitude. High Alt Med Biol 2 : 257–279.
  9. Delpapa EH, Edelstone DI, Milley JR, Balsan M, 1992. Effects of chronic maternal anemia on systemic and uteroplacental oxygenation in near-term pregnant sheep. Am J Obstet Gynecol 166 : 1007–1012.
  10. Paulone ME, Edelstone DI, Shedd A, 1987. Effects of maternal anemia on uteroplacental and fetal oxidative metabolism in sheep. Am J Obstet Gynecol 156 : 230–236.
  11. Capurro H, Korichzky S, Fonseca O, Caldeiro-Barcia R, 1978. A simplified method for diagnosis of gestational age in the newborn infant. J Pediatr 93 : 120–122.
  12. Cohen JH, Haas JD, 1999. Hemoglobin correction factors for estimating the prevalence of iron deficiency anemia in pregnant women residing at high altitude in Bolivia. Pan Am J Public Health 6 : 392–399.
  13. Niermeyer S, Shaffer EM, Thilo E, Corbin C, Moore LG, 1993. Arterial oxygenation and pulmonary arterial pressure in healthy neonates and infants at high altitude. J Pediatr 123 : 767–772.
  14. Mok JY, McLaughlin FJ, Pintar M, Hak H, Amaro–Gálvez R, Levison H, 1986. Transcutaneous monitoring of oxygenation: What is normal? J Pediatr 108 : 365–371.
  15. Prechtl HFR, 1974. The behavioural states of the newborn infant (a review). Brain Res 76 : 185–212.
  16. Fanconi S, 1988. Reliability of pulse oximetry in hypoxic infants. J Pediatr 112 : 424–427.
  17. Madico G, Gilman RH, Jabra A, 1995. The role of pulse oximetry. Its use as an indicator of severe respiratory disease in Peruvian children living at sea level. Arch Pediatr Adolesc Med 149 : 1259–1263.
  18. Ogunbode O, 1980. The relationship between hematocrit levels in gravidae and their newborn. Int J Gynaecol Obstet 18 : 57–60.
  19. Erdem A, Erdem M, Arslan M, Yazici G, Eskandari R, Himmetoglu O, 2002. The effect of maternal anemia and iron deficiency on fetal erythropoiesis: comparison between serum erythropoietin, hemoglobin and ferritin levels in mothers and newborns. J Matern Fetal Neonatal Med 11 : 329–332.
  20. Fagan DG, Lancashire RJ, Walker A, Sorahan T, 1995. Determinants of fetal haemoglobin in newborn infants. Arch Dis Child Fetal Neonatal Ed 72 : F111–F114.
  21. Delivoria-Papadopoulos M, Roncevic NP, Oski FA, 1971. Post-natal changes in oxygen transport of term, premature, and sick infants: the role of red cell 2,3-diphosphoglycerate and adult hemoglobin. Pediatr Res 5 : 235–245.
  22. Gamponia MJ, Babaali H, Yugar F, Gilman RH, 1998. Reference values for pulse oximetry at high altitude. Arch Dis Child 78 : 461–465.
  23. Reuland DS, Steinhoff MC, Gilman RH, Bara M, Olivares EG, Jabra A, Finkelstein D, 1991. Prevalence and prediction of hypoxemia in children with respiratory infections in the Peruvian Andes. J Pediatr 119 : 900–906.
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  • Received : 31 Jul 2003
  • Accepted : 10 Dec 2003

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