Volume 70, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


The susceptibility of 20 isolates of on the Thailand-Myanmar border to seven antimalarial drugs was evaluated using the schizont maturation inhibition technique. The geometric mean 50% inhibition concentration (IC) values were quinine = 308 ng/mL, amodiaquine =14 ng/mL, chloroquine =50 ng/mL, mefloquine = 127 ng/mL, sulfadoxine/pyrimethamine (80:1) = 800/10 ng/mL, pyrimethamine = 8 ng/mL, and artesunate = 0.5 ng/mL. Compared with in this area, was more sensitive to chloroquine and artesunate, equally sensitive to quinine, and more resistant to mefloquine.


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  1. Kidson C, Singhasivanon P, Supavej S, 1999. Mekong Malaria. Southeast Asian J Trop Med Public Health 30 (suppl 4): 28–40. [Google Scholar]
  2. Nosten F, ter Kuile F, Maelankirri L, Decludt B, White NJ, 1991. Malaria during pregnancy in an area of unstable endemicity. Trans R Soc Trop Med Hyg 85 : 424–429. [Google Scholar]
  3. Nosten F, McGready R, Simpson J, Thwai KL, Balkan S, Cho L, Hkirijareon L, Looareesuwan S, White NJ, 1999. Effects of Plasmodium vivax malaria in pregnanacy. Lancet 14 : 546–549. [Google Scholar]
  4. Schuurkamp G, Spicer PE, Kereu RK, Bulungol PK, 1992. Chloroquine resistant P. vivax in Papua New Guinea. Trans R Soc Trop Med Hyg 86 : 121–122. [Google Scholar]
  5. Baird JK, Basri, Purnomo, Bang MJ, Subbianto B, Patchen LC, Hoffmann SL, 1991. Resistance to chloroquine by Plasmodium vivax in Irian Jaya, Indonesia. Am J Trop Med Hyg 44 : 547–555. [Google Scholar]
  6. Soto J, Toledo J, Gutierrz P, Luzz M, Linas N, Cedeno N, Dunne M, Berman J, 2001. Plasmodium vivax clinically resistant to chloroquine in Colombia. Am J Trop Med Hyg 65 : 90–93. [Google Scholar]
  7. Dua VK, Kar PK, Sharma VP, 1996. Chloroquine resistant P. vivax malaria in India. Trop Med Int Health 1 : 816–819. [Google Scholar]
  8. Marlar Than, Myat Phone Kyaw, Aye Yu Soe, Khaing Khaing Gyi, Ma Sabai, Myint Oo, 1995. Development of resistance to chloroquine by P. vivax in Myanmar. Trans R Soc Trop Med Hyg 89 : 307–308. [Google Scholar]
  9. Simpson J, Silamut K, Chotivanich K, Pukrittayakamee S, White NJ, 1999. Red cell selectivity in malaria: a study of multiple infected erythrocytes. Trans R Soc Trop Med Hyg 93 : 165–168. [Google Scholar]
  10. Silamut K, Hough R, Eggelte T, Pukrittayakamee S, Angus B, White NJ, 1995. A simple method for assessing quinine per-treatment in acute malaria. Trans R Soc Trop Med Hyg 89 : 665–667. [Google Scholar]
  11. Brockman A, Price R, van Vugt M, Heppner DG, Walsh D, Sookto P, Wimonwattrawatee T, Looareesuwan S, White NJ, Nosten F, 2000. Plasmodium falciparum antimalarial drug susceptibility on the north-western border of Thailand during five years of extensive use of artesunatemefloquine. Trans R Soc Trop Med Hyg 94 : 537–544. [Google Scholar]
  12. Fevre EM, Barnish G, Yamongul P, Rooney W, 1999. Sensitivity in vitro of Plasmodium falciparum to three currently used antimalarial drugs on the western border of Thailand. Trans R Soc Trop Med Hyg 93 : 180–184. [Google Scholar]
  13. Childs GE, Pang L, Wimonwattrawatee T, Pooyindee N, Nanakorn A, Limchitee S, Webster HK, 1987. In vitro mefloquine resistance of Plasmodium falciparum isolated from the Burmese border region of Thailand. Southeast Asian J Trop Med Public Health 18 : 438–443. [Google Scholar]
  14. Pukrittayakamee S, Chantra A, Simpson J, Vanijanonta S, Clemens R, Looareesuwan S, White NJ, 2000. Therapeutic responses to different antimalarial drugs in vivax malaria. Antimicrob Agents Chemother 44 : 1680–1685. [Google Scholar]
  15. Chulay J, Watkins WM, Sixsmith DG, 1984. Synergistic antimalrial activity of pyrimethamine and sulfadoxine against Plasmodium falciparum in vitro. Am J Trop Med Hyg 33 : 325–330. [Google Scholar]
  16. Brockelman CR, Tan-Ariya P, 1982. Plasmodium falciparum in continuous culture: a new medium for the in vitro test for sulfadoxine sensitivity. Bull World Health Organ 60 : 423–426. [Google Scholar]
  17. Wernsdorfer WH, Landgraf B, Wiedermann G, Kollaritsch H, 1995. Chloroquine resistance of Plasmodium falciparum: a biological advantage? Trans R Soc Trop Med Hyg 89 : 90–91. [Google Scholar]
  18. Tan-Ariya P, Na-Bangchang K, Tin T, Limpaibul L, Brockelman CR, Karbwang J, 1995. Clinical response and susceptibility in vitro of Plasmodim vivax to the standard regimen of chloroquine in Thailand. Trans R Soc Trop Med Hyg 89 : 426–429. [Google Scholar]

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  • Received : 21 Jan 2003
  • Accepted : 17 Sep 2003

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