1921
Volume 70, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

The chloroquine resistance transporter ( K76T mutation and haplotype (amino acids 72–76) and the multidrug resistance 1 ( mutation (N86Y) were analyzed as markers of chloroquine resistance in the DNAs of 73 blood samples from patients with malaria in India. Seventy of the 73 DNAs had the K76T mutation. Of these, 66 had the SVMNT haplotype and four had CVIET, the African/Southeast Asian haplotype. Only 20 of 69 DNAs had the N86Y mutation. It is surprising that the haplotype in India is predominantly SVMNT, rather than that seen in Southeast Asia. The widespread prevalence of the K76T mutation is a cause for concern.

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/content/journals/10.4269/ajtmh.2004.70.256
2004-03-01
2017-11-22
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  • Received : 31 Jul 2003
  • Accepted : 25 Nov 2003

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