Volume 70, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


A study was conducted in Papua New Guinea to analyze drug resistance polymorphisms in patients presenting with resistant malaria. One hundred ninety-nine -positive patients were recruited at two sites, Madang and Maprik. Exposure to the 4-aminoquinolines chloroquine and amodiaquine was uniformly high, at 84% overall. However, 59% of these were taken in various combinations of sulfadoxine/pyrimethamine and/or primaquine and/or quinine. Two markers for 4-aminoquinoline resistance, chloroquine resistance transporter 76T and multidrug resistance 1, were fixed in the population and two markers for pyrimethamine resistance, dihydrofolate reductase () 59R and 108N, were found at moderate to high levels, overall 60% and 75%, respectively. No polymorphisms in associated with sulfadoxine resistance were present. Differences between the two sites are analyzed. The study period encompasses a change in standard malaria treatment policy. These findings stress the need for regular monitoring of the effects of standard drug treatment of uncomplicated malaria in Papua New Guinea.


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  • Received : 27 May 2003
  • Accepted : 04 Nov 2003

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