Volume 70, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Monthly doses of rifampin, ofloxacin, and minocycline (ROM) are expected to be effective treatment for multi-bacillary leprosy. Patients with MB leprosy received ROM (n = 10) or World Health Organization multi-drug therapy (MDT) (n = 11). Treatment with ROM was given as 24 consecutive monthly observed doses of rifampin (600 mg), ofloxacin (400 mg), and minocycline (100 mg). Treatment with MDT was given as 24 consecutive monthly observed doses of rifampin (600 mg) and clofazimine (300 mg), and unobserved daily dapsone (100 mg) and clofazimine (50 mg). Twenty patients completed the 24-month regimens with > 99% compliance. Treatments with ROM and MDT were safe, tolerable, and caused similar improvements in lesions, bacterial indices, and histology. All MDT recipients developed clofazimine-induced pigmentation. Six ROM and nine MDT recipients assessed at five or more years after completion of treatment had no evidence of relapse. Twenty-four months of treatment with ROM is a safe, well-tolerated, and convenient regimen that may provide an alternate therapy to MDT for MB leprosy. Larger trials with sufficient follow-up would better define the role of ROM.


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  1. WHO Study Group, 1982. Chemotherapy of Leprosy for Control Programmes. World Health Organ Tech Rep Ser.
  2. Grosset JH, 2001. Newer drugs in leprosy. Int J Lepr Other Mycobact Dis 69 : S14–S18. [Google Scholar]
  3. WHO Expert Committee on Leprosy, Seventh Report, 1998. World Health Organ Tech Rep Ser 874.
  4. Ji B, 1998. Why multidrug therapy for multibacillary leprosy can be shortened to 12 months. Lepr Rev 69 : 106–109. [Google Scholar]
  5. Lockwood DN, 2002. Leprosy elimination-a virtual phenomenon or a reality? BMJ 324 : 1516–1518. [Google Scholar]
  6. 1997. Leprosy beyond the year 2000 (editorial). Lancet 350 : 1717. [Google Scholar]
  7. Suneetha S, Reddy R, 2001. Histological resolution and bacterial clearance with pulse ROM therapy in borderline lepromatous leprosy. Int J Lepr Other Mycobact Dis 69 : 53–54. [Google Scholar]
  8. Villahermosa LG, Walsh DS, Fajardo TT Jr, Abalos RM, dela Cruz EC, Veerasubramanian P, Walsh GP, 1999. Resolution of lepromatous leprosy after a short course of amoxicillin/ clavulanic acid, followed by ofloxacin and clofazimine. Int J Dermatol 38 : 558–560. [Google Scholar]
  9. Fajardo TT, Abalos RM, dela Cruz EC, Villahermosa LG, Walsh DS, Cellona RV, Balagon MV, Tan EV, Walsh GP, 1999. Clofazimine therapy for lepromatous leprosy: a historical perspective. Int J Dermatol 38 : 70–74. [Google Scholar]
  10. Ji B, Sow S, Perani E, Lienhardt C, Diderot V, Grosset J, 1998. Bactericidal activity of a single-dose combination of ofloxacin plus minocycline, with or without rifampin, against Mycobacterium leprae in mice and in lepromatous patients. Antimicrob Agents Chemother 42 : 1115–1120. [Google Scholar]
  11. Gupte MD, 2000. Field trials of a single dose of the combination rifampicin-ofloxacin-minocycline (ROM) for the treatment of paucibacillary leprosy. Lepr Rev 71 (Suppl): S77–S80. [Google Scholar]
  12. WHO, 1997. MDT, Questions and Answers. World Health Organ Tech Rep Ser , 26–27. [Google Scholar]
  13. World Health Organization, 1998. Model Prescribing Information: WHO Drugs Used in Leprosy. Geneva: World Health Organization, 12–14.
  14. Mane I, Cartel JL, Grosset JH, 1997. Field trial on efficacy of supervised monthly dose of 600 mg rifampin, 400 mg ofloxacin and 100 mg minocycline for the treatment of leprosy; first results. Int J Lepr Other Mycobact Dis 65 : 224–229. [Google Scholar]
  15. Ji B, Jamet P, Sow S, Perani EG, Traore I, Grosset JH, 1997. High relapse rate among lepromatous leprosy patients treated with rifampin plus ofloxacin daily for 4 weeks. Antimicrob Agents Chemother 41 : 1953–1956. [Google Scholar]
  16. Baohong J, 2001. Does there exist a subgroup of MB patients at greater risk of relapse after MDT? Lepr Rev 72 : 3–7. [Google Scholar]
  17. Ridley DS, 1964. Bacterial indices. Cochrane RG, Davey TF, eds. Leprosy in Theory and Practice. Baltimore: Williams and Wilkins, 620–624.
  18. Sehgal VN, Joginder, 1990. Slit-skin smear in leprosy. Int J Dermatol 29 : 9–16. [Google Scholar]
  19. Ridley DS, Jopling WH, 1966. Classification of leprosy according to immunity. A five-group system. Int J Lepr Other Mycobact Dis 34 : 255–273. [Google Scholar]
  20. Ridley DS, Hilson GRF, 1967. A logarithmic index of bacilli in biopsies: I. method; II. evaluation. Int J Lepr Other Mycobact Dis 35 : 184–192. [Google Scholar]
  21. Pattyn S, Grillone S, 2002. Relapse rates and a 10-year follow-up of a 6-week quadruple drug regimen for multibacillary leprosy. Lepr Rev 73 : 245–247. [Google Scholar]
  22. Ji B, 2001. Does dapsone resistance really matter in the MDT era? Int J Lepr Other Mycobact Dis 69 : 54–55. [Google Scholar]
  23. Rao PN, Lakshmi TS, 2001. Increase in the incidence of dapsone hypersensitivity syndrome-an appraisal. Lepr Rev 72 : 57–62. [Google Scholar]
  24. Reeve PA, Ala J, Hall JJ, 1992. Dapsone syndrome in Vanuatu: a high incidence during multidrug treatment (MDT) of leprosy. J Trop Med Hyg 95 : 266–270. [Google Scholar]
  25. Griffiths S, Ready N, 2001. Defaulting patterns in a provincial leprosy control programme in northern Mozambique. Lepr Rev 72 : 199–205. [Google Scholar]
  26. Chen XS, Ye GY, Jiang C, Li WZ, Bian J, Wang H, Chen W, 1997. An investigation of attitudes, beliefs and behaviour of leprosy patients, family members and PHC workers towards multidrug therapy in Yangzhou and Dongtai Districts of China. Lepr Rev 68 : 155–161. [Google Scholar]
  27. Blok LM, Bloos LJ, van den Berg G, 1991. A retrospective study on seven years of multiple drug treatment for paucibacillary and multibacillary leprosy, in Bayara General Hospital, Nigeria. Lepr Rev 62 : 193–200. [Google Scholar]
  28. Grosset JH, Cole ST, 2001. Genomics and the chemotherapy of leprosy. Lepr Rev 72 : 429–440. [Google Scholar]
  29. Gelber RH, 1994. Chemotherapy of lepromatous leprosy: recent developments and prospects for the future. Eur J Clin Microbiol Infect Dis 13 : 942–952. [Google Scholar]
  30. Rao PS, Ramachandran A, Sekar B, Ravi S, Subramanian M, 1994. Ofloxacin-containing combined drug regimens in the treatment of lepromatous leprosy. Lepr Rev 65 : 181–189. [Google Scholar]

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  • Received : 07 Jul 2003
  • Accepted : 25 Sep 2003

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