Volume 70, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


A large proportion of people with latent tuberculosis live in malaria-endemic areas, so co-infection with these two organisms is likely to be common. To determine whether there might be a biologic interaction between these two pathogens , we infected mice with and then with a non-lethal strain of eight weeks later. Mice chronically infected with simulate the equilibrium between pathogen and host thought to exist in human latent infection. Co-infected mice were less able to contain growth of in lung, spleen, and liver (mean ± SEM log colony-forming units = 5.50 ± 0.11 versus 5.12 ± 0.08, 4.58 ± 0.07 versus 4.13 ± 0.10, and 2.86 ± 0.10 versus 2.49 ± 0.10, respectively) and had increased mortality. In populations where both diseases are endemic, there may be implications for increased incidence of clinically detectable tuberculosis.


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  • Received : 24 Oct 2003
  • Accepted : 14 Nov 2003

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