Volume 69, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


The objective of the study was to determine if the presence or absence of virulence factor-positive and -negative enteroaggregative (EAEC) determined the occurrence of illness or sub-clinical EAEC infection in travelers from the United States to Mexico. Sixty-five newly arrived college students from the United States submitted weekly stool samples for a four-week period of time. Among EAEC-infected subjects, diarrhea occurred in those with a defined virulence factor with the following frequency: , 5 of 15 (33%); , 3 of 11 (27%); , 3 of 8 (38%); and , 1 of 6 (17%). Twenty-two of 31 students (71%) had two or more EAEC infections. After the initial EAEC infection, only 4 (11%) of 31 students had a subsequent symptomatic EAEC infection. Our study suggests that clinical illness by EAEC is not explained by presence of a defined EAEC virulence factors, and we provide suggestive evidence that EAEC infection protects against future symptomatic infection.


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  • Received : 16 Jun 2003
  • Accepted : 20 Aug 2003

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