Volume 69, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


B cell-deficient C57Bl/6 (μMT) mice were resistant to after both primary and secondary parasite challenge. However, unlike in wild-type mice, secondary infection in μMT mice was not accompanied by a marked delayed type hypersensitivity-like response, and interferon-γ (IFN-γ) levels were approximately half of those in wild-type mice. These results suggest that B cells are involved in IFN-γ production and the pathology of secondary infection.


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  1. Bogdan C, Gessner A, Solbach W, Rollinghoff M, 1996. Invasion, control and persistence of Leishmania parasites. Curr Opin Immunol 8 : 517–525.
  2. Liew FY, O’Donnell CA, 1993. Immunology of leishmaniasis. Adv Parasitol 32 : 161–259.
  3. Lohoff M, Gessner A, Bogdan C, Röllinghoff M, 1998. The Th1/ Th2 paradigm and experimental murine leishmaniasis. Int Arch Allergy Immunol 115 : 191–202.
  4. Reiner SL, Locksley RM, 1995. The regulation of immunity to Leishmania major. Annu Rev Immunol 13 : 151–177.
  5. Solbach W, Laskay T, 2000. The host response to Leishmania infection. Adv Immunol 74 : 275–317.
  6. Scott P, Natovitz P, Sher A, 1986. B lymphocytes are required for the generation of T cells that mediate healing of cutaneous leishmaniasis. J Immunol 137 : 1017–1021.
  7. Brown DR, Reiner SL, 1999. Polarized helper-T-cell responses against Leishmania major in the absence of B cells. Infect Immun 67 : 266–270.
  8. Babai B, Louzir H, Cazenave PA, Dellagi K, 1999. Depletion of peritoneal CD5+ B cells has no effect on the course of Leishmania major infection in susceptible and resistant mice. Clin Exp Immunol 117 : 123–129.
  9. Sacks DL, Scott PA, Asofsky R, Sher A, 1984. Cutaneous leishmaniasis in antiIgM-treated mice: enhanced resistance due to functional depletion of a B cell-dependent T cell involved in the suppressor pathway. J Immunol 132 : 2072–2077.
  10. Hale C, Howard JG, 1981. Immunological regulation of experimental cutaneous leishmaniasis. 2. Studies with Biozzi high and low responder lines of mice. Parasite Immunol 3 : 45–55.
  11. Olobo JO, Handman E, Curtis JM, Mitchell GF, 1980. Antibodies to Leishmania tropica promastigotes during infection in mice of various genotypes. Aust J Exp Biol Med Sci 58 : 595–601.
  12. Su H, Feilzer K, Caldwell HD, Morrison RP, 1997. Chlamydia trachomatis genital tract infection of antibody-deficient gene knockout mice. Infect Immun 65 : 1993–1999.
  13. Yang DM, Rogers MV, Liew FY, 1991. Identification and characterization of host-protective T-cell epitopes of a major surface glycoprotein (pg63) from Leishmania major. Immunology 72 : 3–9.
  14. Eperon S, Bronnimann K, Hemphill A, Gottstein B, 1999. Susceptibility of B-cell deficient C57Bl/6 (μMT) mice to Neospora caninum infection. Parasite Immunol 21 : 225–236.
  15. Matsuzaki G, Vordermeier HM, Hashimoto A, Nomoto K, Ivanyi J, 1999. The role of B cells in the establishment of T cell response in mice infected with an intracellular bacteria, Listeria monocytogenes. Cell Immunol 194 : 178–185.
  16. Howard JG, Hale C, Liew FY, 1980. Immunological regulation of experimental leishmaniasis. III. Nature and significance of specific suppression of cell-mediated immunity in mice highly susceptible to Leishmania tropica. J Exp Med 152 : 594–607.
  17. Howard JG, Hale C, Liew FY, 1981. Immunological regulation of experimental cutaneous leishmaniasis. IV. Prophylactic effect of sublethal irradiation as a result of abrogation of suppressor T cell generation in mice genetically susceptible to Leishmania tropica. J Exp Med 153 : 557–568.
  18. DeKrey GK, Titus RG, 1999. A method for the isolation and analysis of leucocytic cells from leishmanial ear lesions in mice. J Immunol Methods 228 : 1–11.
  19. Titus RG, DeKrey GK, Morris RV, Suares MBP, 2001. Interleukin-6-deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease. Infect Immun 69 : 5189–5192.
  20. Soares MBP, David JR, Titus RG, 1997. An in vitro model for infection with Leishmania major that mimics the immune response in mice. Infect Immun 65 : 2837–2845.
  21. Harris DP, Haynes L, Sayles PC, Duso DK, Eaton SM, Lepak NM, Johnson LL, Swain SL, Lund FE, 2000. Reciprocal regulation of polarized cytokine production by effector B and T cells. Nature Immunol 1 : 475–482.

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  • Received : 10 Jul 2003
  • Accepted : 22 Aug 2003

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