1921
Volume 69, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Coprologic surveys were carried out in villages of the Behera Governorate in the Nile Delta region of Egypt to characterize the epidemiologic features of human fascioliasis caused by and in this lowland endemic area by comparison with fascioliasis caused by only in areas hyperendemic for human disease in the Andean highlands of South America. The fascioliasis prevalences detected (range = 5.2–19.0%, mean = 12.8%) are the highest obtained in Egypt. The comparison with previous results suggests that in the Nile Delta, fascioliasis is spreading from an original situation of sporadic human cases in well-known endemic foci for animal disease to an endemic distribution in humans, which may be characterized as a mesoendemic region that includes several hyperendemic areas for human disease. As in Andean countries, a relationship with sex was found, although in Egypt prevalences, but not intensities, appeared to be significantly higher in females. All ages appear to be susceptible to liver fluke infection, with prevalences and intensities being lower before and after school age, a situation that is consistent with that detected in Andean countries, although the peak in the 9–11-year-old age group appears less pronounced in Egypt. The intensities were very high when compared with those found in subjects sporadically infected in areas endemic for animal disease, but relatively low for a hyperendemic situation, although the intensities may not be conclusive because of the transmission seasonality of fascioliasis in the Nile Delta. The marked similarities in the qualitative and quantitative spectrums of protozoans and helminths, multiparasitisms, and associations between liver flukes and other parasitic species suggest physiographic-hydrographic and behavioral-social characteristics similar in all areas hyperendemic for human fascioliasis, which are independent of other factors such as climate, altitude, and cultural or religious features. The significant positive association between liver fluke infection and schistosomiasis mansoni detected in one locality has never been described elsewhere, and must be considered relevant from clinical, pathologic, diagnostic, and therapeutic points of view. Interestingly, the relationships of schistosomiasis prevalences and intensities with sex and age follow patterns similar to those found in fascioliasis.

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2003-10-01
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References

  1. Mas-Coma S, Bargues MD, 1997. Human liver flukes: a review.Res Rev Parasitol 57 : 145–218.
  2. Chen MG, Mott KE, 1990. Progress in assessment of morbidity due to Fasciola hepatica infection: a review of recent literature. Trop Dis Bull 87 : R1–R38.
  3. Mas-Coma S, Bargues MD, Marty AM, Neafie RC, 2000. Hepatic trematodiases. Meyers WM, Neafie RC, Marty AM, Wear DJ, eds. Pathology of Infectious Diseases. Volume 1. Helminthiases. Washington, DC: Armed Forces Institute of Pathology and American Registry of Pathology, 69–92.
  4. Esteban JG, Bargues MD, Mas-Coma S, 1998. Geographical distribution, diagnosis and treatment of human fascioliasis: a review. Res Rev Parasitol 58 : 13–42.
  5. Valero MA, Santana M, Morales M, Hernández JL, Mas-Coma S, 2003. The risk of gallstone disease in the advanced chronicity state of fascioliasis: an experimental study in a rat model. J Infect Dis (in press).
  6. Mas-Coma S, Bargues MD, Esteban JG, 1999. Human Fasciolosis. Dalton JP, ed. Fasciolosis. Wallingford, Oxon, United Kingdom: CAB International Publishing, 411–434.
  7. Mas-Coma S, Bargues MD, Valero MA, Fuentes MV, 2003. Adaptation capacities of Fasciola hepatica and their relationships with human fascioliasis: from below sea level up to the very high altitude. Combes C, Jourdane J, eds. Taxonomy, Ecology and Evolution of Metazoan Parasites. Volume II. Perpignan, France: Perpignan University Press, 81–123.
  8. Mas-Coma S, Esteban JG, Bargues MD, 1999. Epidemiology of human fascioliasis: a review and proposed new classification. Bull World Health Organ 77 : 340–346.
  9. Hillyer GV, Soler de Galanes M, Rodríguez-Pérez J, Bjorland J, Silva de Lagrava M, Ramírez Guzmán S, Bryan RT, 1992. Use of the Falcon assay screening test-enzyme-linked immunosorbent assay (FAST-ELISA) and the enzyme-linked immunoelectrotransfer blot (EITB) to determine the prevalence of human fascioliasis in the Bolivian Altiplano. Am J Trop Med Hyg 46 : 603–609.
  10. Mas-Coma S, Angles R, Strauss W, Esteban JG, Oviedo JA, Buchon P, 1995. Human fasciolasis in Bolivia: a general analysis and a critical review of existing data. Res Rev Parasitol 55 : 73–93.
  11. Mas-Coma S, Angles R, Esteban JG, Bargues MD, Buchon P, Franken M, Strauss W, 1999. The northern Bolivian Altiplano: a region highly endemic for human fascioliasis. Trop Med Int Health 4 : 454–467.
  12. Bjorland J, Bryan RT, Strauss W, Hillyer GV, McAuley JB, 1995. An outbreak of acute fascioliasis among Aymara Indians in the Bolivian Altiplano. Clin Infect Dis 21 : 1228–1233.
  13. Esteban JG, Flores A, Aguirre C, Strauss W, Angles R, Mas-Coma S, 1997. Presence of very high prevalence and intensity of infection with Fasciola hepatica among Aymara children from the northern Bolivian Altiplano. Acta Trop 66 : 1–14.
  14. Esteban JG, Flores A, Angles R, Strauss W, Aguirre C, Mas-Coma S, 1997. A population-based coprological study of human fascioliasis in a hyperendemic area of the Bolivian Altiplano. Trop Med Int Health 2 : 695–699.
  15. Esteban JG, Flores A, Angles R, Mas-Coma S, 1999. High endemicity of human fascioliasis between Lake Titicaca and La Paz valley, Bolivia. Trans R Soc Trop Med Hyg 93 : 151–156.
  16. O’Neill SM, Parkinson M, Strauss W, Angles R, Dalton JP, 1998. Immunodiagnosis of Fasciola hepatica (fascioliasis) in a human population in the Bolivian Altiplano using purified cathepsin L cysteine proteinase. Am J Trop Med Hyg 58 : 417–423.
  17. Esteban JG, González, Bargues MD, Angles R, Sánchez C, Naquira C, Mas-Coma S, 2002. High fascioliasis infection in children linked to a man-made irrigation zone in Peru. Trop Med Int Health 7 : 339–348.
  18. Fuentes MV, Valero MA, Bargues MD, Esteban JG, Angles R, Mas-Coma S, 1999. Analysis of climatic data and forecast indices for human fascioliasis at very high altitude. Ann Trop Med Parasitol 93 : 835–850.
  19. Soliman MS, 1998. Control of veterinary fascioliasis. Angelico M, Rocchi G, eds. Infectious Diseases and Public Health. A Research and Clinical Update. Philadelphia: Balaban Publishers, 334–346.
  20. Haseeb AN, El Shazly AM, Arafa MAS, Morsy ATA, 2002. A review on fascioliasis in Egypt. J Egypt Soc Parasitol 32 : 317–354.
  21. WHO, 1995. Control of foodborne trematode infections. World Health Organ Tech Rep Ser 849 : 1–157.
  22. Marcilla A, Bargues MD, Mas-Coma S, 2002. A PCR-RFLP assay for the distinction between Fasciola hepatica and F. gigantica. Mol Cell Probes 16 : 327–333.
  23. Lofty M, El-Morshedy HN, El-Hoda MA, El-Tawila MM, Omar EA, Farag HF, 2002. Identification of the Egyptian species of Fasciola. Vet Parasitol 103 : 323–332.
  24. Mas-Coma S, Funatsu IR, Bargues MD, 2002. Fasciola hepatica and lymnaeid snails occurring at very high altitude in South America. Parasitology 123 : S115–S127.
  25. Curtale F, Nabil M, El Wakeel A, Shamy MY, Behera Survey Team, 1998. Anaemia and intestinal parasitic infections among school age children in Behera Governorate, Egypt. J Trop Pediatr 44 : 323–328.
  26. Curtale F, Hammoud ES, El Wakeel A, Mas-Coma S, Savioli L, 2000. Human fascioliasis, an emerging public health problem in the Nile Delta, Egypt. Res Rev Parasitol 60 : 129–134.
  27. Curtale F, Moursy BEM, El Deen MSS, Nabil M, El Wakeel A, 1997. Operational Research on Health, Nutrition and Environmental Needs in Behera Governorate. Final Report. Strengthening Rural Health Services in Behera, Dakalhia and Qena Governorates. Alexandria, Egypt: Egyptian-Italian Cooperation, Editing and Printing Center, Extension of the Medical Research Institute of Alexandria University.
  28. Ash LR, Orihel TC, Savioli L, 1994. Bench Aids for the Diagnosis of Intestinal Parasites. Geneva: World Health Organization.
  29. Knight WB, Hiatt RA, Cline BL, Ritchie LS, 1976. A modification of the formol-ether concentration technique for increased sensitivity in detecting Schistosoma mansoni. Am J Trop Med Hyg 55 : 818–823.
  30. Henriksen SA, Pohlenz JFL, 1981. Staining of cryptosporidia by a modified Ziehl-Neelsen technique. Acta Vet Scand 22 : 594–596.
  31. Montresor A, Crompton DWT, Bundy DAP, May A, Savioli L, 1998 . Guidelines for the Evaluation of Soil-Transmitted Helminthiasis and Schistosomiasis at Community Level. A Guide for Managers of Control Programmes. Geneva: Schistosomiasis and Intestinal Parasites Unit, Division of Control of Tropical Diseases, World Health Organization, WHO/CTD/SIP/98.1.
  32. Farag HF, Barakat RMR, Ragab M, Omar E, 1979. A focus of human fascioliasis in the Nile Delta, Egypt. J Trop Med Hyg 82 : 188–190.
  33. Hassan MM, Moustafa NE, Mahmoud LA, Abbaza BE, Hegab MH, 1995. Prevalence of Fasciola infection in school children in Sharkia governorate, Egypt. J Egypt Soc Parasitol 25 : 543–549.
  34. El Bahy MM, 1997. Fascioliasis among animal, snail and human hosts in Kafr El-Sheikh Governorate with special reference to species infecting humans. Vet Med J Giza 45 : 187–209.
  35. El Shazly AM, Soliman M, Gabr A, Haseeb AN, Morsy ATA, Arafa MAS, Morsy TA, 2001. Clinico-epidemiological study of human fascioliasis in an endemic focus in Dakahlia governorate, Egypt. J Egypt Soc Parasitol 31 : 725–736.
  36. El Sayed MH, Allam AF, Osman MM, 1997. Prevention of human fascioliasis: a study on the role of acids detergents and potassium permanganate in clearing salads from metacercariae. J Egypt Soc Parasitol 27 : 163–169.
  37. Motawea SM, El Gilany A, Massoud A, Rizk H, El Shazly AM, Gaballah M, 2001. An epidemiological study of fascioliasis in a rural area in Dakahlia Governorate. J Environ Sci 21 : 31–62.
  38. Valero MA, Marti R, Marcos MD, Robles F, Mas-Coma S, 1998. Le mollusque Lymnaea truncatula (Lymnaeidae) dans les rizières de l’Est de l’Espagne. Vie Milieu 48 : 73–78.
  39. Valero MA, Panova MA, Comes AM, Fons R, Mas-Coma S, 2002. Patterns in size and shedding of Fasciola hepatica eggs by naturally and experimentally infected murid rodents. J Parasitol 88 : 308–313.
  40. Farag HF, Salem A, Khalil SS, Farahat A, 1993. Studies on human fascioliasis in Egypt. 1. Seasonality of transmission. J Egypt Soc Parasitol 23 : 331–340.
  41. Esteban JG, Aguirre C, Flores A, Strauss W, Angles R, Mas-Coma S, 1998. High Cryptosporidium prevalences in healthy Aymara children from the northern Bolivian Altiplano. Am J Trop Med Hyg 58 : 50–55.
  42. Esteban JG, Aguirre C, Angles R, Ash LR, Mas-Coma S, 1998. Balantidiasis in Aymara children from the northern Bolivian Altiplano. Am J Trop Med Hyg 59 : 922–927.
  43. Flores A, Esteban JG, Angles R, Mas-Coma S, 2001. Soil-transmitted helminth infections at very high altitude in Bolivia. Trans R Soc Trop Med Hyg 95 : 272–277.
  44. Pointier JP, Paraense WL, Dejong RJ, Loker ES, Bargues MD, Mas-Coma S, 2002. A potential snail host of schistosomiasis in Bolivia: Biomphalaria amazonica Paraense, 1966. Mem Inst Oswaldo Cruz 97 : 793–796.
  45. Van Someren VD, 1946. The habitats and tolerance ranges of Lymnaea (Radix) caillaudi, the intermediate snail host of the liver fluke in East Africa. J Anim Ecol 15 : 170–197.
  46. Brown D, 1994. Freshwater Snails of Africa and Their Medical Importance. Second edition. London: Taylor and Francis, Ltd.
  47. Cheever AW, Neafie RC, 2000. Schistosomiasis. Meyers WM, Neafie RC, Marty AM, Wear DJ, eds. Pathology of Infectious Diseases., Volume 1. Helminthiases. Washington, DC: Armed Forces Institute of Pathology and American Registry of Pathology, 23–48.
  48. Cheever AW, 1968. A quantitative post-mortem study of schistosomiasis mansoni in man. Am J Trop Med Hyg 17 : 38–64.
  49. Lyra LG, Rebouças G, Andrade ZA, 1976. Hepatitis B surface antigen carrier state in hepatosplenic schistosomiasis. Gastroenterology 71 : 641–645.
  50. Frank Ch, Mohamed MK, Strickland GT, Lavanchy D, Arthur RR, Magder LS, El Khoby T, Abdel-Wahab Y, Aly Ohn ES, Anwar W, Sallam I, 2000. The role of parenteral antischistosomal therapy in the spread of hepatitis C virus in Egypt. Lancet 355 : 887–891.
  51. Hillyer GV, 1999. Immunodiagnosis of human and animal fasciolosis. Dalton JP, ed. Fasciolosis. Wallingford, Oxon, United Kingdom: CAB International Publishing, 435–464.
  52. Hassan MM, Farghaly AM, El-Gamal RLR, El-Ridi AMS, 1989. Cross-reactions in immunodiagnosis of patients infected with Schistosoma, Fasciola and Heterophyes using ELISA. J Egypt Soc Parasitol 19 : 845–851.
  53. Azab ME, El-Zayat EA, 1996. Evaluation of purified antigens in haemagglutination test (IHA) for determination of cross reactivities in diagnosis of fascioliasis and schistosomiasis. J Egypt Soc Parasitol 26 : 677–685.
  54. Aaty HEA, Hashim AE, 1996. Evaluation of IHA test for fascioliasis in cases of hepatitis C virus infection. J Egypt Soc Parasitol 26 : 475–480.
  55. Savioli L, Chitsulo L, Montresor A, 1999. New opportunities for the control of fascioliasis (editorial). Bull World Health Organ 77 : 300.
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  • Received : 04 Feb 2003
  • Accepted : 29 May 2003

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