Volume 69, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Toxocariasis is usually manifested as visceral larva migrans. Nervous system involvement is a rare complication. In this report, we describe one case of meningoencephalitis due to and review the literature. We report a previously healthy two-year-old boy who was admitted after 24 hours of severe neurologic symptoms with marked eosinophilic pleocytosis in the cerebrospinal fluid and a single subcortical lesion detected by cerebral magnetic resonance imaging. Both serum and spinal fluid tested positive for . Initial treatment with thiabendazole was ineffective. After marked improvement in clinical and laboratory results were achieved using albendazole and corticosteroids, the child was discharged.


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  1. Nishimura K, Hung T, 1997. Current views on geographic distribution and modes of infection of neurohelminthic diseases. J Neurol Sci 145 : 5–14.
  2. Weller PF, 1993. Eosinophilic meningitis. Am J Med 95 : 250–253.
  3. Lo Re VL III, Gluckman SJ, 2003. Eosinophilic meningitis. Am J Med 114 : 217–223.
  4. Beautyman W, Woolf AL, 1951. An ascaris larva in the brain in association with acute anterior poliomyelitis. J Pathol Bacteriol 63 : 635–647.
  5. Nichols RL, 1956. The etiology of visceral larva migrans. I. Diagnostic morphology of infective second-stage Toxocara larvae. J Parasitol 42 : 349–363.
  6. Beautyman W, Beaver PC, Buckley JJ, Woolf AL, 1966. Review of a case previously reported as showing an ascarid larva in the brain. J Pathol Bacteriol 91 : 271–273.
  7. Bouchard O, Bosseray A, Leclercq P, Micoud M, 1998. Meningo encephalite a Toxocara canis. Ann Med Interne (Paris) 149 : 391–392.
  8. Gould M, Newell S, Green SH, George RH, 1985. Toxocariasis and eosinophilic meningitis. BMJ 291 : 1239–1240.
  9. Hill IR, Denham DA, Scholtz CL, 1985. Toxocara canis larvae in the brain of a British child. Trans R Soc Trop Med Hyg 79 : 351–354.
  10. Mimoso MG, Pereira MC, Estevao MH, Barroso AA, Mota HC, 1993. Eosinophilic meningoencephalitis due to Toxocara canis. Eur J Pediatr 152 : 783–784.
  11. Ota S, Komiyama A, Johkura K, Hasegawa O, Kondo K, 1994. Eosinophilic meningo-encephalo-myelitis due to Toxocara canis. Rinsho Shinkeigaku 34 : 1148–1152.
  12. Robinson A, Tannier C, Magnaval JF, 2002. Toxocara canis meningoradiculitis. Rev Neurol (Paris) 158 : 351–353.
  13. Russegger L, Schmutzhard E, 1989. Spinal toxocaral abscess (letter). Lancet 8659 : 398.
  14. Rüttinger P, Hadidi H, 1991. MRI in cerebral toxocaral disease. J Neurol Neurosurg Psychiatry 54 : 361–362.
  15. Sommer C, Ringelstein EB, Biniek R, Glöckner WM, 1994. Adult Toxocara canis encephalitis. J Neurol Neurosurg Psychiatry 57 : 229–231.
  16. Villano M, Cerillo A, Narciso N, Vizioli L, del Basso de Caro M, 1992. A rare case of Toxocara canis arachnoidea. J Neurosurg Sci 36 : 67–69.
  17. Wang C, Huang CY, Chan PH, Preston P, Chau PY, 1983. Transverse myelitis associated with larva migrans: finding of larva in cerebrospinal fluid (letter). Lancet 8321 : 423.
  18. Zachariah SB, Zachariah B, Varghese R, 1994. Neuroimaging studies of cerebral “visceral larva migrans” syndrome. J Neuroimaging 4 : 39–40.
  19. Magnaval JF, Galindo V, Glickman LT, Clanet M, 1997. Human Toxocara infection of the central nervous system and neurological disorders: a case-control study. Parasitology 115 : 537–543.
  20. Jung H, Hurtado M, Sanchez M, Medina MT, Sotelo J, 1990. Plasma and CSF levels of albendazole and praziquantel in patients with neurocysticercosis. Clin Neuropharmacol 13 : 559–564.
  21. Pearson RD, 2000. Agents active against parasites and Pneumocystis carinii. Mandell GL, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Diseases. Philadelphia: Churchill Livingstone, 505–539.
  22. Pawlowski Z, 2001. Toxocariasis in humans: clinical expression and treatment dilemma. J Helminthol 75 : 299–305.
  23. Chotmongkol V, Sawanyawisuth K, Thavornpitak Y, 2000. Corticosteroid treatment of eosinophilic meningitis. Clin Infect Dis 31 : 660–662.
  24. Jung H, Hurtado M, Medina MT, Sanchez M, Sotelo J, 1990. Dexamethasone increases plasma levels of albendazole. J Neurol 273 : 279–280.

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  • Received : 26 Mar 2003
  • Accepted : 07 Jul 2003

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