Volume 69, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Post-treatment reactions to single-dose ivermectin (200 μg/kg) and albendazole (400 mg) were studied in a filarial endemic region of Mali. The prevalence of in this region was 48.3% (69 of 143), and coinfection with was common (30 of 40, 75%). Microfilarial levels of correlated positively with age ( = 0.006) and with microfilarial levels ( = 0.006). Forty individuals (28 infected and 12 uninfected) were treated, with mild post-treatment reactions occurring in 35.7% (7 of 28) of the -infected subjects. Reaction severity correlated with pretreatment microfilarial levels ( = 0.001). There were no significant differences in the prevalence or severity of post-treatment reactions in those who were co-infected with . It is concluded that co-infection with does not significantly alter the post-treatment reaction profile to single-dose ivermectin/albendazole in infection in this community, and that acute post-treatment reactions should not limit patient compliance in community-based programs to eliminate lymphatic filariasis.


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  • Received : 03 Apr 2003
  • Accepted : 01 Jul 2003

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