1921
Volume 69, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Adult golden hamsters inoculated subcutaneously with either of two sandfly fever group viruses, Punta Toro and Gabek Forest (), developed a fulminating fatal illness characterized by hepatic and splenic necrosis and interstitial pneumonitis. Most animals died within three days after infection; this was accompanied by high levels of viremia. Necropsy and histopathologic examination of the infected animals revealed pathologic changes involving multiple organs that resembled those described in Rift Valley fever. These two hamster-phlebovirus systems may serve as alternative animal models for Rift Valley fever and should be useful in studying the pathogenesis of severe phlebovirus infection and for testing potential therapeutic agents.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2003.69.269
2003-09-01
2017-09-22
Loading full text...

Full text loading...

/deliver/fulltext/14761645/69/3/0690269.html?itemId=/content/journals/10.4269/ajtmh.2003.69.269&mimeType=html&fmt=ahah

References

  1. Gear JHS, 1988. Rift Valley fever. Gear JHS, ed. CRC Handbook of Viral and Rickettsial Hemorrhagic Fevers. Boca Raton, FL: CRC Press, 101–118.
  2. Meegan JM, Bailey CL, 1989. Rift Valley fever. Monath TP, ed. The Arboviruses: Epidemiology and Ecology. Volume 5. Boca Raton, FL: CRC Press, 51–76.
  3. Peters CJ, 1997. Emergence of Rift Valley fever. Saluzzo JF, Dodet B, eds. Factors in the Emergence of Arbovirus Disease. Paris: Elsevier, 253–264.
  4. Elliott RM, Bouloy M, Calisher CH, Goldbach R, Moyer JT, Nichol ST, Pettersson R, Pluysnin A, Schmaljohn CS, 2000. Family Bunyaviridae. van Regenmortel MHV, Fauquet CM, Bishop DHL, Carstens EB, Estes MK, Lemon SM, Maniloff J, Mayo MA, McGeoch DJ, Pringle CR, Wickner RB, eds. Virus Taxonomy. Classification and Nomenclature of Viruses. Seventh Report of the International Committee on Taxonomy of Viruses. San Diego: Academic Press, 559–621.
  5. Centers for Disease Control and Prevention, 2000. Outbreak of Rift Valley fever – Saudi Arabia, August-October, 2000. MMWR Morb Mortal Wkly Rep 49 : 905–908.
  6. Peters CJ, 2000. Are hemorrhagic fever viruses practical agents for biological terrorism? Sheld WM, Craig WA, Hughes JM, eds. Emerging Infections 4. Washington, DC: American Society for Microbiology Press, 201–209.
  7. National Institute of Allergy and Infectious Diseases, 2002. The Counter-Bioterrorism Research Agenda of the National Institute of Allergy and Infectious Diseases (NIAID) for CDC Category A Agents. Bethesda: National Institutes of Health.
  8. Centers for Disease Control and Prevention/ National Institutes of Health, 1999. Biosafety in Microbiological and Biomedical Laboratories . Fourth edition. Washington, DC: U.S. Government Printing Office.
  9. Easterday BC, 1965. Rift Valley fever. Adv Vet Sci 10 : 65–127.
  10. Daubney R, Hudson J, Garnham P, 1931. Enzootic hepatitis or Rift Valley fever. An undescribed virus disease of sheep, cattle, and man from East Africa. J Pathol Bacteriol 34 : 545–579.
  11. Findlay GM, 1932. Rift Valley fever or enzootic hepatitis. Trans R Soc Trop Med Hyg 25 : 229–265.
  12. Tesh RB, Duboise SM, 1987. Viremia and immune response with sequential phlebovirus infections. Am J Trop Med Hyg 36 : 662–668.
  13. Anderson G, Slayter M, Hall W, Peters CJ, 1990. Pathogenesis of a phleboviral infection (Punta Toro virus) in golden Syrian hamsters. Arch Virol 114 : 203–212.
  14. Karabatsos N, 1985. International Catalogue of Arboviruses Including Certain Other Viruses of Vertebrates. Third edition. San Antonio, TX: American Society of Tropical Medicine and Hygiene.
  15. Xiao S-Y, Zhang H, Guzman H., Tesh R, 2001. Experimental yellow fever virus infection in golden hamster (Mesocricetus auratus): II. Pathology. J Infect Dis 183 : 1437–1444.
  16. Tesh R, Guzman H, Travassos da Rosa A, Vasconcelos P, Dias L, Bunnell J, Zhang H, Xiao S-Y, 2001. Experimental yellow fever virus infection in the golden hamster (Mesocricetus auratus). I. Virologic, biochemical and immunologic studies. J Infect Dis 183 : 1431–1436.
  17. Xiao S-Y, Guzman H, Travassos da Rosa APA, Zhu H-B, Tesh RB, 2003. Alteration of clinical outcome and histopathology of yellow fever virus infection in a hamster model by previous infection with heterologous flaviviruses. Am J Trop Med Hyg 68 : 695–703.
  18. Mims CAC, 1957. Rift Valley fever in mice. VI. Histological changes in the liver in relation to virus multiplication. Aust J Exp Biol Med Sci 35 : 595–604.
  19. Findlay GM, 1933. Cytological changes in the liver of Rift Valley fever, with special reference to the nuclear inclusions. Br J Exp Pathol 14 : 207–219.
  20. Swaneppoel R, Manning B, Watt JA, 1979. Fatal Rift Valley fever of man in Rhodesia. Centr Afri J Med 25 : 1–8.
  21. Abdel-Wahab KSED, Baz LME, 1978. Rift Valley fever virus infections in Egypt: pathological and virological findings in man. Trans R Soc Trop Med Hyg 72 : 392–396.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2003.69.269
Loading
/content/journals/10.4269/ajtmh.2003.69.269
Loading

Data & Media loading...

  • Received : 27 Feb 2003
  • Accepted : 27 May 2003

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error