1921
Volume 69, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Amodiaquine, a 4-aminoquinoline compound, is being considered as an alternative to chloroquine and pyrimethamine/sulfadoxine where resistance in to both drugs has been selected. Although amodiaquine is more potent than chloroquine, its effectiveness is reduced in areas where chloroquine resistance is high. We report an association of the chloroquine resistance transporter () gene and the multiple drug resistance 1 () gene, two chloroquine resistance markers, with chloroquine and amodiaquine efficacy in southern Sudan. The data show that the allele of the gene with a lysine to threonine change at codon 76 is strongly associated with both chloroquine and amodiaquine resistance. No such association was observed with the gene.

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2003-08-01
2017-11-23
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  • Received : 10 Feb 2003
  • Accepted : 12 May 2003

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