1921
Volume 68, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

RTS,S/AS02 is a recombinant protein malaria vaccine that contains a large portion of the C-terminal of the circumsporozoite protein (CSP) sequence of the NF54 isolate of fused to the hepatitis B virus surface antigen. It has been shown to induce significant protection to challenge infection with a homologous parasite strain in American volunteers. In a recently completed trial in semi-immune Gambian adults, vaccine efficacy against natural infection was 34% (95% confidence interval = 8–53%, = 0.014) during the malaria season following vaccination. Breakthrough parasites sampled from vaccinated subjects and from controls were genotyped at two polymorphic regions of the gene encoding T cell epitopes ( and ) to determine if the vaccine conferred a strain-specific effect. The overall distribution of allelic variants was similar in infections occurring in vaccine and control groups. Also, the mean number of genotypes per infection in the RTS,S/AS02 group was not reduced compared with the controls.

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2003-01-01
2017-11-22
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  • Received : 28 Jan 2002
  • Accepted : 29 Apr 2002

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