Volume 68, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


An open randomized controlled study of mefloquine-artesunate and mefloquine-primaquine for the treatment of uncomplicated malaria was carried out in Kanchanaburi in the Saiyok District in western Thailand. Weekly parasite counts from thick and thin blood films were done for six weeks. The gametocyte carriage rate was calculated and compared between the two treatment groups. Gametocytes on presentation, recrudescent infection, and reinfection were the significant factors associated with subsequent development of gametocytemia. It is the increased propensity of recrudescent infections to produce gametocytes that drives drug resistance. The results of this study confirmed that the complete eradication of asexual forms of by effective antimalarial treatment, but not by combination treatment with primaquine, is the most effective means to prevent subsequent gametocytemia.


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  • Received : 07 May 2002
  • Accepted : 22 Jan 2003

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