1921
Volume 68, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

An open randomized controlled study of mefloquine-artesunate and mefloquine-primaquine for the treatment of uncomplicated malaria was carried out in Kanchanaburi in the Saiyok District in western Thailand. Weekly parasite counts from thick and thin blood films were done for six weeks. The gametocyte carriage rate was calculated and compared between the two treatment groups. Gametocytes on presentation, recrudescent infection, and reinfection were the significant factors associated with subsequent development of gametocytemia. It is the increased propensity of recrudescent infections to produce gametocytes that drives drug resistance. The results of this study confirmed that the complete eradication of asexual forms of by effective antimalarial treatment, but not by combination treatment with primaquine, is the most effective means to prevent subsequent gametocytemia.

Loading

Article metrics loading...

The graphs shown below represent data from March 2017
/content/journals/10.4269/ajtmh.2003.68.620
2003-05-01
2018-12-19
Loading full text...

Full text loading...

/deliver/fulltext/14761645/68/5/0680620.html?itemId=/content/journals/10.4269/ajtmh.2003.68.620&mimeType=html&fmt=ahah

References

  1. Looareesuwan S, Olliaro P, White NJ, Chongsuphajaisiddhi T, Sabcharoen A, Thimasarn K, Nosten F, Singhasivanon P, Supavej S, Khusmith S, Wylings S, Kanyok T, Walsh D, Leggat PA, Doberstyn EB, 1998. Consensus recommendation on the treatment of malaria in Southeast Asia. Southeast Asian J Trop Med Public Health 29 : 355–360. [Google Scholar]
  2. Nosten F, van Vugt M, Price R, Luxemburger C, Thway KL, Brockman A, McGready R, ter Kuile F, Looareesuwan S, 2000. Effects of artesunate-mefloquine combination on incidence of Plasmodium falciparum malaria and mefloquine resistance in western Thailand: a prospective study. Lancet 356 : 297–302. [Google Scholar]
  3. Price RN, Nosten F, Luxemburger C, ter Kuile F, Paiphun L, Chongsuphajaisiddhi T, White NJ, 1996. Effects of artemisinin derivatives on malaria transmissibility. Lancet 347 : 1654–1658. [Google Scholar]
  4. Strickland T, Fox E, Sarwar M, Khaliq AA, Macdonald M, 1986. Effects of chloroquine, amodiaquine and pyrimethamine-sulfadoxine on Plasmodium falciparum gametocytemia. Am J Trop Med Hyg 35 : 259–262. [Google Scholar]
  5. Sinden RE, 1983. Sexual development of malaria parasites. Adv Parasitol 22 : 153–216. [Google Scholar]
  6. Jeffery G, Eyles DE, 1955. Infectivity to mosquitoes of Plasmodium falciparum as related to gametocyte density and duration of infection. Am J Trop Med Hyg 4 : 781–789. [Google Scholar]
  7. Rieckmann KH, McNamara JV, Kass L, Powell RD, 1969. Gametocytocidal and sporontocidal effects of primaquine upon two strains of Plasmodium falciparum. Mil Med 134 : 802–819. [Google Scholar]
  8. Jeffery G, Young MD, Eyles DE, 1956. The treatment of Plasmodium falciparum infection with chloroquine, with a note on infectivity to mosquitoes of primaquine- and pyrimethamine-treated cases. Am J Hyg 64 : 1–11. [Google Scholar]
  9. Chin W, Rattanarithikul M, 1973. The evaluation of the presumptive and radical treatments against falciparum malaria in Thailand. Southeast Asian J Trop Med Public Health. 4 : 400–405. [Google Scholar]
  10. WHO, 2000. Severe falciparum malaria. Trans R Soc Trop Med Hyg 94 (Supp1): S1/1–S1/90. [Google Scholar]
  11. Brockman A, Paul RE, Anderson T, Hackford I, Phaiphun L, Looareesuwan S, Nosten F, Day KP, 1999. Application of genetic markers to the identification of recrudescent Plasmodium falciparum infections on the northwestern border of Thailand. Am J Trop Med Hgy 60 : 14–21. [Google Scholar]
  12. Nosten F, Ter Kuile F, Chongsuphajaisiddhi T, Luxemburger C, Webster HK, Edstein M, Paiphun L, Thew KL, White NJ, 1991. Mefloquine-resistant falciparum malaria on the Thai-Burmese border. Lancet 337 : 1140–1143. [Google Scholar]
  13. White NJ, 1999. Antimalarial drug resistance and combination chemotherapy. Philos Trans R Soc Lond B Biol Sci 354 : 739–749. [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2003.68.620
Loading
/content/journals/10.4269/ajtmh.2003.68.620
Loading

Data & Media loading...

  • Received : 07 May 2002
  • Accepted : 22 Jan 2003

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error