1921
Volume 68, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

While a number of microbial infections induce a transient burst in viral load in individuals infected with human immunodeficiency virus-1 (HIV-1), a recent study has suggested that scrub typhus may suppress HIV-1 infection. We investigated the effects of on HIV-1 infection. HIV-1 infection experiments were conducted using peripheral blood mononuclear cells (PBMC) acutely infected with R5 and X4 HIV-1 or PBMC derived from patients receiving highly active antiretroviral therapy (HAART) whose plasma viral load was undetectable. Stimulation of PBMC with induced production of proinflammatory cytokines and β-chemokines, and markedly down-regulated expression of CCR5. Although pretreatment with rendered PBMC resistant to R5 HIV-1, it otherwise enhanced HIV-1 replication. Stimulation by induced HIV-1 replication in PBMC from patients receiving HAART. These findings suggest that scrub typhus does not necessarily suppress HIV-1 infection and does have potential to enhance HIV-1 replication.

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2003-05-01
2017-09-23
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  • Received : 22 Apr 2002
  • Accepted : 20 Jan 2003

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