1921
Volume 68, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

In 1993, Malawi stopped treating patients with chloroquine for malaria because of a high treatment failure rate (58%). In 1998, the resistance rate to chloroquine was 3% in the Salima District of Malawi; in 2000, the resistance rate was 9%. We assayed two genetic mutations implicated in chloroquine resistance (N86Y in the multiple drug resistance gene 1 and K76T in the chloroquine resistance transporter gene) in 82 isolates collected during studies in 1998 and 2000. The prevalence of N86Y remained similar to that in neighboring African countries that continued to use chloroquine. In contrast, the prevalence of K76T was substantially lower than in neighboring countries, decreasing significantly from 17% in 1998 to 2% in 2000 ( < 0.02). However, neither mutation was significantly associated with or resistance ( > 0.29). Withdrawal of the use of chloroquine appears to have resulted in the recovery of chloroquine efficacy and a reduction in the prevalence of K76T. However, other polymorphisms are also expected to contribute to resistance.

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2003-04-01
2017-07-28
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  • Received : 07 Aug 2002
  • Accepted : 03 Jan 2003

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