Volume 68, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


The EG95-based vaccine protects sheep from infection with the dog tapeworm The EG95 encoding gene is a member of a multigene family, several members of which are expressed in the oncosphere, believed to be the target of immunity induced by the vaccine. exhibits extensive intraspecific (strain) variation, and variability of the 95 gene in different isolates of may directly impact the effectiveness of the EG95-based vaccine. We analyzed the 95 gene from collected in Xinjiang, in northwest China, where hydatid disease is hyperendemic. The gene is expressed in oncospheres, protoscoleces, and immature and mature adult worms, and the 95 gene family was shown to comprise two basic sequence types. Very limited sequence variation was evident in the EG95 protein from oncospheres. This high degree of sequence conservation predicts that the vaccine will continue to be effective in China and elsewhere.


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  • Received : 29 Apr 2002
  • Accepted : 11 Sep 2002

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