1921
Volume 68, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Mutations in the chloroquine resistance transporter () gene were examined to assess their associations with chloroquine resistance in clinical samples from Armopa (Papua) and Papua New Guinea. In Papua, two of the five haplotypes found were new: SVIET from Armopa and CVIKT from an isolate in Timika. There was also a strong association ( < 0.0001) between the 76T allele and chloroquine resistance in 50 samples. In Papua New Guinea, mutations in the gene were observed in 15 isolates with chloroquine minimum inhibitory concentrations (MICs) of 16–64 pmol, while the remaining six isolates, which had a wild-type gene at codon 76, had MICs of 2–8 pmol. These observations confirm that mutations at codon 76 in the gene are present in both and cases of chloroquine resistance, and that detection of the 76T allele could predict potential chloroquine treatment failures.

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2003-04-01
2017-09-26
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  • Received : 09 Sep 2002
  • Accepted : 04 Dec 2002

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