Volume 68, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


The purpose of this study was to evaluate the efficacy and the tolerance of nitazoxanide in children as a single broad-spectrum antiparasitic agent in the treatment of mixed parasite infections with both intestinal protozoa and helminths. Two hundred seventy-two children (age range = 2–14 years) participated in this study. We systematically surveyed every household head using questionnaires designed to obtain information about household socioeconomic status and hygiene. Parasitic infections were confirmed by three stool examinations using direct smear, Ferreira concentration, and cold acid-fast Kinyoun staining methods. One hundred twenty-one (44%) children tested positive for protozoa such as (18%), (10%), (7%), (4%), and (3%), and helminths such as (10%), (6%), and (6%). There were also two cases of infection with . After a complete physical examination was performed, 121 patients received treatment with nitazoxanide. Overall, 84% of the protozoa and 95% of the helminths were completely eliminated from the patients. Nitazoxanide was very well tolerated, with no serious adverse effects reported.


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  1. Rossignol JF, Cavier R, 1975. New derivative of 2-benzamido-5-nitrothiols. Chem Abs 83 : 28216.
    [Google Scholar]
  2. Rossignol JF, Maisonneuve H, 1984. Nitazoxanide in the treatment of Taenia saginata and Hymenolepis nana infections. Am J Trop Med Hyg 33 : 511–512.
    [Google Scholar]
  3. Rossignol JF, Abaza H, Friedman H, 1998. Successful treatment of fasciolosis with nitazoxanide. Trans R Soc Trop Med Hyg 92 : 103–104.
    [Google Scholar]
  4. Doumbo O, Rossignol JF, Pichard E, Traore HA, Dembele M, Diakite M, Traore F, Diallo DA, 1997. Nitazoxanide in the treatment of cryptosporidial diarrhea and other intestinal parasitic infections associated with acquired immunodeficiency syndrome in tropical Africa. Am J Trop Med Hyg 56 : 637–639.
    [Google Scholar]
  5. Romero CR, Robert GL, Muñoz GMR, Geyne CA, 1997. Nitazoxanide for the treatment of intestinal protozoan and helminthic infections in Mexico. Trans R Soc Trop Med Hyg 91 : 701–703.
    [Google Scholar]
  6. Abaza H, El-Zayali A, Kabil SM, Rizk H, 1998. Nitazoxanide in the treatment of patients with intestinal protozoan and helminthic infections: a report on 546 patients in Egypt. Curr Ther Res 59 : 116–121.
    [Google Scholar]
  7. Garcia L, Bullock-Iacullo S, Fritsche T, Healy G, McAuley J, Neimeister R, Palmer J, Wilson M, Wong J, 1997. Procedures for Recovery and Identification of Parasites from the Intestinal Tract. Approved Guideline. Wayne, PA: National Committee for Clinical and Laboratory Standards, 17 : 8–10 and 25–27.
  8. Biagi F, Portilla J, 1957. Comparison of methods of examining stools for parasites. Am J Trop Med Hyg 6 : 906–911.
    [Google Scholar]
  9. Henriksen SA, Pohlenz JFL, 1981. Staining cryptosporidia by a modified Ziehl-Nielsen technique. Acta Vet Scand 22 : 594–596.
    [Google Scholar]
  10. Ortiz J, Ayoub A, Gargala G, Chegne N, Favennec L, 2001. Randomized clinical study of nitazoxanide compared to metronidazole in the treatment of symptomatic giardiasis in children from northern Peru. Aliment Pharmacol Ther 15 : 1409–1415.
    [Google Scholar]

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  • Received : 15 Mar 2002
  • Accepted : 18 Nov 2002
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