Volume 68, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Co-infection of human immunodeficiency virus and malaria is not uncommon in people living in sub-Saharan Africa. Since HIV infection results in immune deficiency, it may alter the ability of HIV patients to mount proper immune responses against malaria parasites. We measured specific malaria antibodies in 47 specimens from 25 couples from Kinshasa, Democratic Republic of the Congo (DRC), according to their HIV status, and investigated probable interaction between malaria and HIV infection. Plasma samples were analyzed for HIV markers (western blot and viral load) and malaria parasite-specific antibody (antibody titer, pattern of antigen recognized by western blotting, and parasite neutralizing antibodies assayed by growth inhibition). No correlation was identified between measured HIV infection status and malaria-specific parameters.


Article metrics loading...

The graphs shown below represent data from March 2017
Loading full text...

Full text loading...



  1. WHO: Fact Sheet 94 (revised October 1998).
  2. UNAIDS, 2000. AIDS Epidemic Update: December 2000.
  3. Fowke KR, Kaul R, Rosenthal KL, Oyugi J, Kimani J, Rutherford WJ, Nagelkerke NJ, Ball TB, Bwayo JJ, Simonsen JN, Shearer GM, Plummer FA, 2000. HIV-1-specific cellular immune responses among HIV-1-resistant sex workers. Immunol Cell Biol 78 : 586–595. [Google Scholar]
  4. Hoffman SL, Sedegah M, Malik A, 1994. Cytotoxic T lymphocytes in humans exposed to Plasmodium falciparum by immunization or natural exposure. Curr Top Microbiol Immunol 189 : 187–203. [Google Scholar]
  5. Whitworth J, Morgan D, Quigley M, Smith A, Mayanja B, Eotu H, Omoding N, Okongo M, Malamba S, Ojwiya A, 2000. Effect of HIV-1 and increasing immunosuppression on malaria parasitemia and clinical episodes in adults in rural Uganda: a cohort study. Lancet 356 : 1051–1056. [Google Scholar]
  6. Kalyesubula I, Musoke-Mudido P, Marum L, Bagenda D, Aceng E, Ndugwa C, Olness K, 1997. Effects of malaria infection in HIV-1-infected Ugandan children. Ped Inf Dis J 16 : 876–881. [Google Scholar]
  7. Greenberg AE, Watso N, Ryder RW, Mvula M, Matadi N, Nsimba K, Matela B, Nsuami M, Davachi F, Hassig SE, 1991. Plasmodium falciparum and perinatally acquired human immunodeficiency virus type 1 infection in Kinshasa, Zaire. N Engl J Med 325 : 105–109. [Google Scholar]
  8. Nguyen-Dinh P, Greenberg AE, Mann JM, Kabote N, Francis H, Colebunders RL, Houng AY, Quinn TC, Davachi F, Lyamba B, Kalemba K, Embonga B, 1987. Absence of association between Plasmodium falciparum malaria and human immunodeficiency virus infection in children in Kinshasa, Zaire. Bull WHO 65 : 607–613. [Google Scholar]
  9. Allen S, Van de Perre P, Serufilira A, Lepage P, Carael M, Declercq A, Tice J, Black D, Nsengumuremyi F, Ziegler J, 1991. HIV and malaria in a representative sample of childbearing women in Kigali, Rwanda. J Inf Dis 164 : 67–71. [Google Scholar]
  10. Hoffman IF, Jere CS, Taylor TE, Munthali P, Dyer JR, Wirima JJ, Rogerson SJ, Kumwenda N, Eron JJ, Fiscus SA, Chakraborty H, Taha TE, Cohen MS, Molyneux ME, 1999. The effect of Plasmodium falciparum malaria on HIV-1 RNA blood plasma concentration. AIDS 13 : 487–494. [Google Scholar]
  11. Pisell TL, Hoffman IF, Jere CS, Ballard SB, Molyneux ME, Butera ST, Lawn SD, 2002. Immune activation and induction of HIV-1 replication within CD14 macrophages during acute Plasmodium falciparum malaria coinfection. AIDS 16: 1503–1509. [Google Scholar]
  12. Kumar N, Folgar JP, Lubega P, 1992. Recognition of Plasmodium falciparum asexual stage antigens by antibodies in sera from people exposed to Plasmodium vivax. Am J Trop Med Hyg 47 : 422–428. [Google Scholar]
  13. Trager W, Jensen JB, 1976. Human malaria parasites in continuous culture. Science 193 : 673–675. [Google Scholar]
  14. Rhee MSM, Akanmori BD, Waterfall M, Riley EM, 2001. Changes in cytokine production associated with acquired immunity to Plasmodium falciparum malaria. Clin Exp Immunol 126 : 503–510. [Google Scholar]
  15. Dodoo K, Omer FM, Todd J, Akanmori BD, Koram KA, Riley EM, 2002. Absolute levels and ratios of proinflammatory and anti-inflammatory cytokine production in vitro predict clinical immunity to Plasmodium falciparum malaria. J Inf Dis 185 : 971–979. [Google Scholar]

Data & Media loading...

  • Received : 27 Aug 2002
  • Accepted : 30 Oct 2002

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error