1921
Volume 68, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

We evaluated the growth inhibitory effect of triclosan, which has recently been reported to inhibit the growth of and , on bovine and equine parasites in cultures. The growth of and was significantly inhibited in the presence of 100 μg/ml of triclosan, while and were susceptible to as low as 50 μg/ml. and were completely cleared as early as on the first and second day of the treatment, respectively. These parasites did not exhibit any growth in the subsequent five-day period of subculture without triclosan. Drug-treated parasites appeared pycnotic and atypically shaped, and ultrastructurally showed pronounced vacuolations, leading to complete destruction of parasites. Light microscopy showed that used concentrations of triclosan showed no toxicity against the host cells. The results suggest that triclosan can be used for chemotherapy of babesiosis.

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  • Received : 29 Jul 2002
  • Accepted : 25 Nov 2002

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