1921
Volume 68, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Areas of low endemicity of Hansen’s disease, such as Texas, California, and Hawaii, exist due to immigration and rare autochthonous infections. Managing this disease in these areas of low endemicity is difficult, especially in observing for relapse. The accurate diagnosis of relapse is imperative so that appropriate therapy can be promptly reinstituted and unnecessary treatment can be avoided. To assess treatment failures in an area of low endemicity, we retrospectively evaluated 113 patients with Hansen’s disease treated in southern Texas. Of 57 patients who completed therapy, 11 were later restarted on medications for this disease for presumed relapse. However, nine of the 11 were found not to have true relapses of Hansen’s disease. The accurate diagnosis of relapse of this disease is essential not only in the individual patient but also for prospective treatment trials to establish best practices.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2003.68.233
2003-02-01
2017-09-25
Loading full text...

Full text loading...

/deliver/fulltext/14761645/68/2/0680233.html?itemId=/content/journals/10.4269/ajtmh.2003.68.233&mimeType=html&fmt=ahah

References

  1. Ooi WW, Moschella SL, 2001. Update on leprosy in immigrants in the United States: status in the year 2000. Clin Infect Dis 32 : 930–937.
  2. U.S. Department of Health and Human Services, CDC, 2001. Summary of notifiable diseases, United States, 1999. MMWR Morb Mortal Wkly Rep 48 : 1–101.
  3. World Health Organization, 1998. World Health Organization Expert Committee on Leprosy. Seventh Report. World Health Organ Tech Rep Ser 874.
  4. Sehgal VN, Jain S, Charya SN, 1996. Persisters, relapse (reactivation), drug resistance and multidrug therapy (MDT): uniform diagnostic guidelines for leprosy are needed. J Dermatol 23 : 905–907.
  5. Girdhar BK, Girdhar A, Kumar A, 2000. Relapses in multibacillary leprosy patients: effect of length of therapy. Lepr Rev 71 : 144–153.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2003.68.233
Loading
/content/journals/10.4269/ajtmh.2003.68.233
Loading

Data & Media loading...

  • Received : 01 Apr 2002
  • Accepted : 15 Aug 2002

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error