Volume 68, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Molecular studies on scabies, a disease of considerable human and veterinary significance, have been limited because of the difficulty of obtaining the causative organism the “itch mite.” We have used skin from the bedding of crusted scabies patients as a source of mites for the construction of libraries of cDNAs from var. in the bacteriophage λ vector λZAP express. Sequences of 145 clones established that the libraries predominantly contain sequences from enabling a major sequencing program to begin. Among those sequenced to date, cDNAs encoding homologues of 3 house dust mite allergens—the M-177 apolipoprotein, glutathione S-transferase, and paramyosin—were identified. The availability of cDNA libraries from var. and var. and the emerging public sequence databases from both opens up new possibilities in scabies research.


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  • Received : 07 Jan 2002
  • Accepted : 27 Jun 2002

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