1921
Volume 103, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

This study aimed to evaluate the primary symptoms, comorbidities, and outcomes of inpatients with confirmed reverse transcription–PCR (RT-PCR) for SARS-CoV-2 infection among 2077 suspected/diagnosed cases of COVID-19. Based on the results of Least Absolute Shrinkage and Selection Operator (LASSO) logistic regression, age, and suggestive chest X-ray (CXR) findings for SARS-CoV-2 infection, cardiovascular diseases, diabetes mellitus, chronic lung diseases, and intensive care units admission had significant associations with positive RT-PCR results for COVID-19 infection. Also, the highest area under the curve (AUC) was related to cough (AUC = 0.53, 95% CI: 0.51–0.56), dyspnea (AUC = 0.52, 95% CI: 0.50–0.54), and abnormal CXR (AUC = 0.52, 95% CI: 0.50–0.54), as significant predictors. This study showed that some symptoms including cough and dyspnea, as well as abnormal CXR, could be proper predictors of positive RT-PCR result for SARS-CoV-2 infection. It seems that patients with underlying disease(s), such as cardiovascular diseases, diabetes mellitus, and chronic lung diseases, had a higher probability to have positive RT-PCR for SARS-CoV-2 infection than those with no underlying disease(s).

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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References

  1. World Health Organization, 2020. Coronavirus Disease 2019 (COVID-19). Situation Report—138. Available at: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200612-covid-19-sitrep-144.pdf?sfvrsn=66ff9f4f_2. Accessed June 12, 2020.
    [Google Scholar]
  2. Hantoushzadeh S, Norooznezhad AH, 2020. Inappropriate antibiotic consumption as a possible cause of inflammatory storm and septic shock in patients diagnosed with coronavirus-19 disease (COVID-19). Arch Med Res 51: 347348.
    [Google Scholar]
  3. Rodriguez-Morales AJ et al., 2020. Clinical, laboratory and imaging features of COVID-19: a systematic review and meta-analysis. Travel Med Infect Dis 34: 101623.
    [Google Scholar]
  4. Liu K, Chen Y, Lin R, Han K, 2020. Clinical features of COVID-19 in elderly patients: a comparison with young and middle-aged patients. J Infect 80: e14e18.
    [Google Scholar]
  5. World Health Organization, 2020. Coronavirus Disease 2019 (COVID-19). Situation Report–31. Available at: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200220-sitrep-31-covid-19.pdf?sfvrsn=dfd11d24_2. Accessed April 20, 2020.
    [Google Scholar]
  6. Fang Y, Zhang H, Xie J, Lin M, Ying L, Pang P, Ji W, 2020. Sensitivity of chest CT for COVID-19: comparison to RT-PCR. Radiology, doi: 10.1148/radiol.2020200432.
    [Google Scholar]
  7. Ai T, Yang Z, Hou H, Zhan C, Chen C, Lv W, Tao Q, Sun Z, Xia L, 2020. Correlation of chest CT and RT-PCR testing in coronavirus disease 2019 (COVID-19) in China: a report of 1014 cases. Radiology, doi: 10.1148/radiol.2020200642.
    [Google Scholar]
  8. Salehi S, Abedi A, Radmard AR, Sorouri M, Gholamrezanezhad A, 2020. Chest computed tomography manifestation of coronavirus disease 2019 (COVID-19) in patients with cardiothoracic conditions. J Thorac Imaging, doi: 10.1097/RTI.0000000000000531.
    [Google Scholar]
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  • Received : 19 May 2020
  • Accepted : 17 Jun 2020
  • Published online : 24 Jun 2020
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