1921
Volume 102, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has become a public health emergency of international concern. This was first noted in Wuhan, Hubei Province, China, and since then has become widespread globally. We report a 71-year-old woman with documented viral shedding (based on reverse transcription–polymerase chain reaction (RT-PCR) testing) of SARS-CoV-2 for 60 days from the onset of symptoms (55 days from her first positive test and 36 days after complete resolution of symptoms). This is to our knowledge the longest duration of viral shedding reported to date. This case demonstrates that viral shedding after COVID-19 diagnosis can be prolonged.

[open-access] This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Loading

Article metrics loading...

The graphs shown below represent data from March 2017
/content/journals/10.4269/ajtmh.20-0275
2020-04-27
2020-09-28
Loading full text...

Full text loading...

/deliver/fulltext/14761645/102/6/tpmd200275.html?itemId=/content/journals/10.4269/ajtmh.20-0275&mimeType=html&fmt=ahah

References

  1. Phelan AL, Katz R, Gostin LO, 2020. The novel coronavirus originating in Wuhan, China: challenges for global Health Governance. JAMA 323: 709710.
    [Google Scholar]
  2. Worldmeters, 2020. Available at: https://www.worldometers.info/coronavirus/?utm_campaign=homeAdvegas1?. Assessed April 10, 2020.
  3. Qian GQ, Chen XQ, Lv DF, Ma AHY, Wang LP, Yang NB, Chen XM, 2020. Duration of SARS-CoV-2 viral shedding during COVID-19 infection. Infect Dis (Lond) 0: 12. Available at: https://www.tandfonline.com/doi/abs/10.1080/23744235.2020.1748705.
    [Google Scholar]
  4. Xu K et al., 2020. Factors associated with prolonged viral RNA shedding in patients with COVID-19. Clin Infect Dis. Available at: https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa351/5818308.
    [Google Scholar]
  5. Zhou F et al., 2020. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 395: 10541062.
    [Google Scholar]
  6. Li T, Kang X, Zhang B, Shangen Z, Bo L, Tiantian Y, Fan Y, Wang Q, Miao H, 2020. A Special Case of COVID-19 with Long Duration of Viral Shedding for 49 Days. Available at: https://www.medrxiv.org/content/10.1101/2020.03.22.20040071v1.full.pdf+html. Accessed April 19, 2020.
    [Google Scholar]
  7. General Office of National Health Commission, General Office of National Administration of Traditional Chinese Medicine, 2020. Diagnostic and treatment - protocol for Novel Coronavirus Pneumonia (Trial version 5, revised form). Available at: http://www.gov.cn/zhengce/zhengceku/2020-02/09/content_5476407.htm. Accessed February 8, 2020.
    [Google Scholar]
  8. China National Health Commission, 2020. Diagnosis and Treatment of 2019-nCoV Pneumonia in China. In Chinese. Available at: http://www.nhc.gov.cn/yzygj/s7653p/202002/d4b895337e19445f8d728fcaf1e3e13a.shtml.
    [Google Scholar]
  9. Zou L et al., 2020. SARS-CoV-2 viral load in upper respiratory specimens of infected patients. N Engl J Med 382: 11771179.
    [Google Scholar]
  10. Rothe C et al., 2020. Transmission of 2019-nCoV infection from an asymptomatic contact in Germany. N Engl J Med 382: 970971.
    [Google Scholar]
  11. Lan L, Xu D, Ye G, Xia C, Wang S, Li Y1, Xu H, 2020. Positive RT-PCR test results in patients recovered from COVID-19. JAMA 323: 15021503.
    [Google Scholar]
  12. Ye F, Xu S, Rong Z, Xu R, Liu X, Deng P, Liu H, Xu X, 2020. Delivery of infection from asymptomatic carriers of COVID-19 in a familial cluster. Int J Infect Dis. Available at: https://www.sciencedirect.com/science/article/pii/S1201971220301740?via%3Dihub.
    [Google Scholar]
  13. Huang L, Zhang X, Zhang X, Wei Z, Zhang L, Xu J, Liang P, Xu PY, Zhang C, Xu PA, 2020. Rapid asymptomatic transmission of COVID-19 during the incubation period demonstrating strong infectivity in a cluster of youngsters aged 16-23 years outside Wuhan and characteristics of young patients with COVID-19: a prospective contact-tracing study. J Infect. Available at: https://www.sciencedirect.com/science/article/pii/S0163445320301171?via%3Dihub.
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.20-0275
Loading
/content/journals/10.4269/ajtmh.20-0275
Loading

Data & Media loading...

  • Received : 11 Apr 2020
  • Accepted : 19 Apr 2020
  • Published online : 27 Apr 2020
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error