1921
image of Case Report: Unusual Presentation of Pharyngeal Mucosal Leishmaniasis due to Leishmania (Viannia) braziliensis
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Mucosal leishmaniasis (ML) affects predominantly the nose and occurs usually weeks or months after the cure of the primary cutaneous lesion. The pathology of ML is characterized by an exaggerated inflammatory reaction with infiltration of lymphocytes, macrophages, and plasma cells. There is also a paucity of parasites and a strong delayed-type hypersensitivity reaction. Herein, we report a case of a young man who had a large ulcer in his left leg and complained of dysphagia. In nasofibrolaryngoscopy, there were nodular lesions in the oropharynx and rhinopharynx. The skin lesion biopsy showed a chronic inflammation with amastigotes inside macrophages, and DNA of confirmed the diagnosis of ML in tissue biopsied from the pharynx. The leishmaniasis skin test was negative. Cytokine evaluation showed lack of production of IFN-γ, IL-1β, and IL-17 with enhancement of these cytokine levels after cure.

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/content/journals/10.4269/ajtmh.20-0219
2020-08-03
2020-09-22
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http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.20-0219
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  • Received : 27 Mar 2020
  • Accepted : 14 Jun 2020
  • Published online : 03 Aug 2020
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