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Authors’ addresses: S. Mann, T. Phupitakphol, and A. Henao-Martínez, Division of Infectious Diseases, University of Colorado School of Medicine, Aurora, CO, E-mails: [email protected], [email protected], and [email protected]. B. Davis, Division of Pathology, University of Colorado School of Medicine, Aurora, CO, E-mail: [email protected]. S. Newman, Division of Dermatology, University of Colorado School of Medicine, Aurora, CO, E-mail: [email protected]. J. A. Suarez, Unidad Clínica de Investigación, Clínica de Medicina Tropical, Instituto Conmemorativo Gorgas de Estudios de la Salud (ICGES), Panamá City, Panamá, E-mail: [email protected]. C. Franco-Paredes, Division of Infectious Diseases, University of Colorado School of Medicine, Aurora, CO and Hospital Infantil de México, Federico Gómez, México City, México, E-mail: [email protected].
Abstract.
We present two cases of Leishmania (V) panamensis in returning travelers from Central America successfully treated with miltefosine. The couple presented with ulcerative skin lesions nonresponsive to antibiotics. Skin biopsy with polymerase chain reaction (PCR) revealed L. (V) panamensis. To prevent the development of mucosal disease and avoid the inconvenience of parental therapy, we treated both patients with oral miltefosine. We suggest that miltefosine represents an important therapeutic alternative in the treatment of cutaneous lesions caused by L. panamensis and in preventing mucosal involvement.