1921
Volume 103, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract.

The prevalence of malaria in India is decreasing, but it remains a major concern for public health administration. The role of submicroscopic malaria and asymptomatic malaria parasitemia and their persistence is being explored. A cross-sectional survey was conducted in the Kandhamal district of Odisha (India) during May–June 2017. Blood samples were collected from 1897 individuals for screening of asymptomatic parasitemia. Samples were screened using rapid diagnostic tests (RDTs) and examined microscopically for species. Approximately 30% of randomly selected samples ( = 586) were analyzed using real-time PCR (qPCR), and the genetic diversity of was analyzed. The prevalence of species among asymptomatic individuals detected using qPCR was 18%, which was significantly higher than that detected by microscopy examination (5.5%) or RDT (7.3%). Of these, 37% had submicroscopic malaria. The species-specific prevalence among asymptomatic malaria-positive cases for , , and mixed infection ( and ) by qPCR was 57%, 29%, and 14%, respectively. The multiplicity of infection was 1.6 and 1.2 for the merozoite surface protein-1 gene () and (), respectively. Expected heterozygosity was 0.64 and 0.47 for and , respectively. A significant proportion of the study population, 105/586 (18%), was found to be a reservoir for malaria infection, and identification of this group will help in the development of elimination strategies.

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/content/journals/10.4269/ajtmh.20-0018
2020-08-10
2020-10-31
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  • Received : 08 Jan 2020
  • Accepted : 17 Jun 2020
  • Published online : 10 Aug 2020
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