1921
Volume 61, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Artemether-lumefantrine is a new fixed antimalarial combination effective against multidrug-resistant falciparum malaria. A prospective electrocardiographic study was conducted in 150 patients receiving artemetherlumefantrine and 50 treated with artesunate-mefloquine. There was no evidence for clinically significant changes in the electrocardiographic intervals and in particular no relationship between plasma concentrations of lumefantrine and QTc prolongation. Artemether-lumefantrine does not have significant cardiac effects at therapeutic doses.

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/content/journals/10.4269/ajtmh.1999.61.964
1999-12-01
2017-11-20
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