1921
Volume 58, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Pulmonary fibrosis was induced following inoculation of Paracoccidioides brasiliensis conidia intranasally in BALB/c mice. Fibrosis was associated with formation of granulomas, increase in lung hydroxyproline, and sustained increases in tissue tumor necrosis factor-alpha and transforming growth factor-beta. This study suggests a role for these cytokines in generation of pulmonary fibrosis associated with chronic granulomatous infectious diseases.

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/content/journals/10.4269/ajtmh.1998.58.424
1998-04-01
2017-11-19
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