Volume 56, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Forty-nine infections with the Malayan IV strain of were induced in different species of monkeys. The parasite was shown to be infective to four different species of monkeys via the inoculation of parasitized erythrocytes. Sporozoite transmission was obtained to , and hybrid monkeys with × and × parentage. and mosquitoes fed readily on animals and through membranes; both supported the development of infective sporozoites. Markedly increased levels of mosquito infection were routinely obtained by membrane feeding, indicating the presence of serum factors inhibitory to infection. The Malayan IV strain appears suitable for blood-stage and transmission-blocking vaccine trials.


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