1921
Volume 56, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract

Monoclonal antibodies (MAbs) to the fraction 1 (F1) protein of protected mice against fatal pneumonic as well as bubonic plague from wild-type F1+ organisms. The rare isolation of a virulent F1- isolate from surviving animals supports earlier studies suggesting that improved vaccines should consist of immunogens to protect against F1 - variants. The high degree of protection with IgG MAb suggests that secretory IgA is not required for protection from pneumonic plague.

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