Volume 55, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Infection with the human pathogenic parasite has not been well-characterized in northeastern Brazil. In this study, the prevalence of infection in a slum in northeastern Brazil was assayed using an enzyme-linked immunosorbent assay (ELISA) for antibodies against the galactose/N-acetyl-D-galactosamine (Gal/GalNAc)-inhibitable adherence lectin of . Sera from a total of 335 individuals were examined for anti-Gal/GalNAc lectin antibodies. The overall seropositivity was 24.7%; 29.4% of females and 19.4% of males were positive. Among different age groups there was a peak of 40% positivity in the 6–14-year-old age group. There was also familial clustering of seropositivity. To examine colonization, stool samples from 155 people were examined microscopically for the presence of the parasite. Fourteen of 155 stools (9.0%) were identified as containing or nonpathogenic . These 14 positive stools were analyzed with an ELISA that detects Gal/GalNAc lectin antigen and can distinguish between and . Four stools (29%) were positive for and the remaining 10 were identified as -positive. Although the overall colonization rate by microscopy was only 9%, with a third identified as , up to 40% of older children develop serologic evidence of having experienced pathogenic infection. The results of this study demonstrate that this community in northeastern Brazil is highly endemic for with infection rates similar to other developing nations.


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