Volume 55, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



A randomized trial carried out in rural Zanzibar comparing a single dose of 200 µg/kg of ivermectin and 400 mg/day for three days of albendazole for treatment of strongyloidiasis and other intestinal nematodes is described. In 301 children with infection, treatment with ivermectin or albendazole resulted in cure rates of 83% and 45%, respectively. While both drugs were very effective against was cured only in 11% (ivermectin) and 43% (albendazole) of the subjects, although the mean eggload was reduced by 59% and 92%, respectively. Ivermectin was ineffective against hookworms, while albendazole resulted in a cure rate of 98%. No severe side effects were recorded and mild side effects were of transient nature for both treatments. Therefore, ivermectin provides a safe and highly effective single dose treatment for and , while it is not an alternative for the treatment of and hookworm infections.


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