Volume 54, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Insect-reared were experimentally fed with the blood of naturally infected human volunteers carrying gametocytes of . Infection of at least one mosquito was successful in 86 experiments. For these gametocyte carriers, the hemoglobin types studied were AA (normal, n = 77), AS (heterozygous sickle cell, n = 8), and SS (homozygous sickle cell, n = 1). The mean of the percentages of infected mosquitoes by gametocyte carriers of AS hemoglobin was almost double that of carriers of AA: 30.4% versus 17.5%. The genetic protection in humans conferred by the β gene in its heterozygous form seems to be associated with an increasing effect on transmission from humans to mosquitoes. The epidemiologic and evolutionary aspects of this finding are discussed.


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