1921
Volume 54, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Abstract

Insect-reared were experimentally fed with the blood of naturally infected human volunteers carrying gametocytes of . Infection of at least one mosquito was successful in 86 experiments. For these gametocyte carriers, the hemoglobin types studied were AA (normal, n = 77), AS (heterozygous sickle cell, n = 8), and SS (homozygous sickle cell, n = 1). The mean of the percentages of infected mosquitoes by gametocyte carriers of AS hemoglobin was almost double that of carriers of AA: 30.4% versus 17.5%. The genetic protection in humans conferred by the β gene in its heterozygous form seems to be associated with an increasing effect on transmission from humans to mosquitoes. The epidemiologic and evolutionary aspects of this finding are discussed.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1996.54.111
1996-02-01
2017-09-23
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1996.54.111
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error