Volume 53, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



An antigen, designated here as the parasitized erythrocyte membrane antigen (PEMA), is present in the erythrocyte membrane surrounding all intraerythrocytic stages of . An antibody specific for PEMA appeared in 21 (50%) of 42 antisera from monkeys naturally infected with . Of these 42 sera, nine (21.4%) contained antibody to the ring-infected erythrocyte membrane antigen (RESA); of these nine sera, six did not react with PEMA. Sera of humans infected with reacted with PEMA and RESA in a similar pattern; i.e., of 83 antisera, 71 (85.5%) reacted with PEMA and 30 (36%) reacted with RESA. Only one of these latter 30 sera were not reactive with PEMA. Of 167 sera from humans infected with but not , 133 (79.6%) reacted with RESA; of these, 43 (25.7% of the total) reacted with PEMA but not RESA. Although PEMA was demonstrated with and RESA with , neither PEMA or RESA could be demonstrated with . Interactions of PEMA and RESA and the corresponding antibodies offer a method whereby the two morphologically similar quartan species, and , can be readily distinguished from each other and may furnish clues to genetic separation of the two and the mechanisms of interaction of quartan malaria and where they are coendemic.


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