Volume 53, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The in vitro activity of atovaquone (566C80) was evaluated and compared with that of chloroquine, quinine, mefloquine, halofantrine, artemether, pyrimethamine, and cycloguanil against African isolates and clones of using an isotopic, semimicro, drug susceptibility test. Atovaquone was highly active against the chloroquine-susceptible L-3 (geometric mean 50% inhibitory concentration [IC] = 0.978 nM) and L-16 clones (mean IC = 0.680 nM) and against the multidrug-resistant FCM 29 clone (mean IC = 1.76 nM). Similar low IC values for atovaquone were observed against the chloroquine-susceptible isolates (n = 35; geometric mean IC = 0.889 nM) and the chloroquine-resistant parasites (n = 26; geometric mean IC = 0.906 nM). The in vitro responses between atovaquone and the other antimalarial drugs were not correlated, indicating the absence of in vitro cross-resistance. The high in vitro activity of atovaquone without any in vitro evidence for cross-resistance with other antimalarial drugs against the naturally occurring malaria parasites is a factor that favors further development of the drug for clinical use.


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