1921
Volume 53, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Abstract

Potential diagnostic indicators of onchocerciasis (subcutaneous nodules, depigmentation or leopard skin, microfilaruria, diethylcarbamazine patch test positivity, excoriations, and pruritus) were evaluated in a rain forest region of southern Cameroon for usefulness in rapid assessment of onchocerciasis endemicity in communities. Thirty-two study villages were selected, representing high, intermediate, and low prevalence levels, and 846 adult male residents of these communities 20 or more years of age were examined according to a defined protocol. Skin snips (from each iliac crest) served as the reference standard. Skin snip positivity was 75.5%; the effect of age was minimal. Leopard skin and nodules showed the strongest correlation with both the skin snip prevalence and community microfilarial load, as reflected by the adult male study population. We selected ≥ 20% nodules or ≥ 20% leopard skin as the most appropriate local criteria for assigning a community to high priority for control, which corresponds to a ≥ 90% skin snip prevalence in adult males. While this criteria should not be applied to regions with savannah onchocerciasis, we believe the methodology can and should be used to determine appropriate diagnostic indicators for rapid assessment of endemicity in regions with different dynamics of transmission and clinical expression of disease.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1995.53.243
1995-09-01
2017-09-20
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1995.53.243
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error