1921
Volume 52, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

Chemical methods specific for the determination of the levels of trivalent antimony (Sb) and pentavalent antimony (Sb) were used to investigate proprietary formulas used to treat leishmaniasis. Trivalent antimony was determined by differential pulse polarography, whereas Sb was determined by iodine titration. Proprietary formulas based on N-meglumine antimoniate (Glucantime) were analyzed in detail. The results showed Sb in all ampules of Glucantime. In formulations said to contain either 85 or 100 mg of Sb/ml, we found both forms of antimony. The amount of Sb ranged from 10.5 to 15.8% (10.06–18.96 mg of Sb/ml). These findings raise issues on product stability and standardization and may help to clarify resistance to antimonial drugs and the reducing effect of tissue on Sb.

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/content/journals/10.4269/ajtmh.1995.52.435
1995-05-01
2017-11-19
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