1921
Volume 52, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
USD

Abstract

Abstract

Gamma camera scintigraphy of dogs infected with radiolabeled third-stage larvae of was successful for visualizing larval migration in a live host. Ten-day-old pups were infected subcutaneously in a lateral inguinal site with 100,000 Se-selenomethionine-labeled third-stage and imaged serially using a clinical gamma camera during the prepatent period. Radioactivity corresponding to the larval inoculum was visualized at the infection site immediately after injection. Radioactivity spread diffusely, corresponding to radial dispersal of larvae from the infection site. The majority of the radioactivity concentrated over or through the abdomen from 48 to 144 hr after infection. Larvae arrived in the small intestine in numbers adequate for visualization beginning at 114 hr after infection. At no time was there concentration of radioactivity associated with the lungs of an infected pup. A control pup injected only with Se-selenomethionine showed uniform activity diffusely throughout the entire body at all times. We concluded that the majority of larvae moved to the gut by means other than the pulmonary route.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.1995.52.236
1995-03-01
2017-09-26
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.1995.52.236
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error