1921
Volume 51, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

Sera of inhabitants of Angola village in central Sudan were investigated for the prevalence of antibodies to , and by the microimmunofluorescence (MIF) test. Clinical examination of 616 persons showed that the village is hyperendemic for trachoma. Of the 448 children examined, 334 (75%) had signs of active trachoma. The corresponding prevalence in the 168 adults was 25%. Using MIF, antibodies to were found in the sera of 27 (81%) children and of 37 (88%) adults with trachoma. Antibodies to occurred in 13% and 24% of the preschool and school trachomatous children, respectively, and in 64% of the adults, which reflects earlier exposure to in the Sudan than generally reported from temperate zones. Antibodies to were found in 6% of the children less than 16 years old and in 17% of the adults. Of the patients with trachoma, 16% had antibodies to both and . The prevalence of multiple antibodies to increased with age. Antibodies to all three species occurred in 3% of the patients. The study does not support the existence of protective immunity between , and , as shown by the high prevalence of chlamydial antibodies in the hyperendemic trachoma community studied.

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/content/journals/10.4269/ajtmh.1994.51.489
1994-10-01
2017-11-23
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