1921
Volume 50, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

A chloroquine-sensitive strain of , F32, from Tanzania was exposed during continuous culture to concentrations of artemisinin, 10–10 M. with exposure times ranging from 1 to 96 hr. After drug exposure, the cultures were washed and the incubation was continued for one or two parasite cycles to assess the remaining viability of the parasites. Artemisinin at a concentration of 10 M inhibited parasite growth by 63% within 3 hr of drug exposure. The parasitemia then continued to decrease after removing the drug by washing the cultures. A 95% inhibition was thus observed 48 hr later. For 100% inhibition, at least 12 hr of exposure to 10 M artemisinin was required. The compound at a concentration of 10 M inhibited growth by 86% within 24 hr of drug exposure and by 98% 48 hours after removing the drug. A concentration of 3 × 10 M exhibited 97–100% inhibition only after 72 or 96 hr of drug exposure, while 10 M did not have any appreciable effect on the growth of the parasites even after 96 hr. It is concluded that artemisinin at high concentrations has a significant rapid in vitro effect that appears to be highly parasitocidal. The compound appears to have a broad spectrum of action, not only schizontocidal as reported earlier, but also against the asexual blood stages of .

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/content/journals/10.4269/ajtmh.1994.50.771
1994-06-01
2017-09-22
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