1921
Volume 50, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

Abstract

The sporontocidal activity of three 8-aminoquinolines, a 1,4-naphthoquinone, and three dihydroacridine-diones was determined against the ANKA clone of and both chloroquine-sensitive (NF54) and chloroquine-resistant (7G8) mosquitoes previously fed on -infected mice or -infected cultures were refed on uninfected mice treated previously with a given drug. Sporontocidal activity was determined by assessing both oocyst and sporozoite development. Neither primaquine nor menoctone exhibited sporontocidal activity against or either strain of at a dose of 100 mg base drug/kg mouse body weight, whereas the other five compounds each effectively interrupted the sporogonic development of all three parasite strains at this dose. These data clearly demonstrate that experimental dihydroacridine-diones and 8-aminoquinolines are capable of interrupting the sporogonic development of and chloroquine-sensitive and chloroquine-resistant . These data also suggest that the model may be used to accurately predict sporontocidal activity against .

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/content/journals/10.4269/ajtmh.1994.50.646
1994-05-01
2017-09-24
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