Volume 50, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



We have concluded initial preclinical studies with synthetic trioxanes numbered and have compared them with artemisinin (numbered ) using CD-1 mice infected with . Based on their antimalarial effectiveness in mice, two of these synthetic trioxanes were selected for evaluation in monkeys infected with multidrug-resistant (MDR) . Trioxane numbered (12 and 48 mg/kg), trioxane numbered (12 and 48 mg/kg) and arteether (numbered , 48 mg/kg) were administered intramuscularly in three 12-hr doses to (Panamanian owl monkeys) infected with the Vietnam Smith/RE strain of and monitored for parasitemia. Trioxane numbered at 12 mg/kg cleared parasitemia in two monkeys, but recrudescence occurred in one animal. Treatment of the recrudescent infection with 48 mg/kg was curative. Infections in two monkeys treated initially with 48 mg/kg were cured (six-month follow-up). Trioxane numbered produced a similar outcome: 12 mg/kg suppressed parasitemia in two monkeys but was not curative; however, 48 mg/kg cured infections in all four monkeys treated. These preliminary observations show synthetic trioxanes numbered and to be as effective as arteether (numbered ) against MDR in in the monkey.


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